Local excision and external beam radiotherapy in early rectal cancer

被引:32
作者
Valentini, V
Morganti, AG
DeSantis, M
Vecchio, FM
Coco, C
Picciocchi, A
Cellini, N
机构
[1] UNIV CATTOLICA SACRO CUORE, IST ANAT PATOL, ROME, ITALY
[2] UNIV CATTOLICA SACRO CUORE, IST PATOL CHIRURG, ROME, ITALY
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 1996年 / 35卷 / 04期
关键词
rectal neoplasms; radiotherapy; local excision; prognostic factors;
D O I
10.1016/0360-3016(96)00133-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To assess the local control and survival of local excision and postoperative radiation in patients with early stage rectal cancer. Methods and Materials: From 1980 to 1992, 21 patients with clinical stage T1-2NxM0 adenocarcinoma of the middle and lower rectum were treated with transanal excision and postoperative external beam radiotherapy (44.6 Gy), The pathologic T stages were: 9 T1 (43%) and 12 T2 (57%), One patient had unassessable resection margins, The median follow-up was 54 months (range: 18-128 months), Results: The actuarial local recurrence-free survival at 5 years was 85.2%, and the overall survival at 5 years was 80.6%. One patient developed a local recurrence and distant metastases at 22 months, and two patients had local recurrence at 11 and 15 months, respectively; both had abdomino-perineal resection (APR) and one remained free of disease 16 months after APR, The incidence of Grade 3 diarrhea was 5%, Sphincter function was good to excellent in the 18 patients with local control, No patients developed clinical evidence of pelvic lymph node recurrence, Conclusion: These results are similar to other published series and suggest that this approach is feasible in selected patients with T1-2NxM0 rectal cancer and results in good long-term control of the disease.
引用
收藏
页码:759 / 764
页数:6
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