Ribosome structure and the mechanism of translation

被引：647

作者：

Ramakrishnan, V ^{[1
]}

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

来源：

CELL | 2002年 / 108卷 / 04期

关键词：

D O I：

10.1016/S0092-8674(02)00619-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The publication of crystal structures of the 50S and 30S ribosomal subunits and the intact 70S ribosome is revolutionizing our understanding of protein synthesis. This review is an attempt to correlate the structures with biochemical and genetic data to identify the gaps and limits in our current knowledge of the mechanisms involved in translation.

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页码：557 / 572

页数：16

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