Early Assessment of Renal Resistance Index and Long-Term Renal Function in Renal Transplant Recipients

被引：21

作者：

Akgul, Arzu ^{[1
]}

Ibis, Avsin ^{[1
]}

Sezer, Siren ^{[1
]}

Basaran, Ceyla ^{[2
]}

Usluogullari, Alper ^{[3
]}

Ozdemir, Fatma Nurhan ^{[1
]}

Arat, Zubeyde ^{[1
]}

Haberal, Mehmet ^{[4
]}

机构：

[1] Baskent Univ, Fac Med, Dept Nephrol, TR-06490 Ankara, Turkey

[2] Baskent Univ, Fac Med, Dept Radiol, TR-06490 Ankara, Turkey

[3] Baskent Univ, Fac Med, Dept Internal Med, TR-06490 Ankara, Turkey

[4] Baskent Univ, Fac Med, Dept Gen Surg, TR-06490 Ankara, Turkey

来源：

RENAL FAILURE | 2009年 / 31卷 / 01期

关键词：

chronic allograft nephropathy; graft failure; renal resistance index;

D O I：

10.1080/08860220802546347

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Background. The effect of the intrarenal arterial resistance index (RI) on long-term renal functions is not well known. We examined the predictive value of intrarenal RI on long-term allograft outcomes. Methods. We retrospectively investigated 121 stable renal transplant recipients, followed for a mean of 63.21 19.9 months after renal transplant. Patients with complications during the first six months after transplant were not included. Color Doppler ultrasonography was done to calculate the intrarenal RI within the first four weeks after transplant. Results. Older recipient age, high pulse pressure, active smoking, and proteinuria were associated with a higher intrarenal RI. Multivariate analyses revealed that renal RI and donor age were independent predictors of allograft outcome. Kaplan-Meier estimates of cumulative graft survival were significantly worse in patients who had an RI of 0.7 or more than they were in patients who had an RI of less than 0.7 (p = .005). Development of chronic allograft nephropathy (CAN) was significantly higher in patients who had an RI of 0.7 or more (p = .02). Conclusions. Renal RI determined within the first month after renal transplant predicts long-term allograft function and development of CAN in renal transplant recipients.

引用

页码：18 / 24

页数：7

共 28 条

[1]

Kreis H.A., Ponticelli C., Causes of late renal allograft loss: Chronic allograft dysfunction, death, and other factors, Transplantation, 71, 11 SUPPL., (2001)

[2]

Paul L.C., Immunologic risk factors for chronic renal allograft dysfunction, Transplantation, 71, pp. 17-23, (2001)

[3]

Fellstrom B., Nonimmune risk factors for chronic renal allograft dysfunction, Transplantation, 71, pp. 10-16, (2001)

[4]

Meyer M., Paushter D., Steinmuller D.R., The use of duplex Doppler ultrasonography to evaluate renal allograft dysfunction, Transplantation, 50, 6, pp. 974-978, (1990)

[5]

Heine G.H., Girndt M., Sester U., Kohler H., No rise in renal Doppler resistance indices at peak serum levels of cyclosporin A in stable kidney transplant patients, Nephrol Dial Transplant, 18, 8, pp. 1639-1643, (2003)

[6]

Krumme B., Grotz W., Kirste G., Schollmeyer P., Rump L.C., Determinants of intrarenal Doppler indices in stable renal allografts, J Am Soc Nephrol, 8, 5, pp. 813-816, (1997)

[7]

Radermacher J., Mengel M., Ellis S., Stuht S., Hiss M., Schwarz A., Eisenberger U., Burg M., Luft F.C., Gwinner W., Haller H., The renal arterial resistance index and renal allograft survival, N Engl J Med, 349, 2, pp. 115-124, (2003)

[8]

Pape L., Mengel M., Offner G., Melter M., Ehrich J.H., Strehlau J., Renal arterial resistance index and computerized quantification of fibrosis as a combined predictive tool in chronic allograft nephropathy, Pediatr Transplant, 8, 6, pp. 565-570, (2004)

[9]

Scolari M.P., Cappuccilli M.L., Lanci N., La Manna G., Comai G., Persici E., Todeschini P., Faenza A., Stefoni S., Predictive factors in chronic allograft nephropathy, Transplant Proc, 37, 6, pp. 2482-2484, (2005)

[10]

Kahraman S., Genctoy G., Cil B., Yilmaz R., Arici M., Altun B., Erdem Y., Yasavul U., Bakkaloglu M., Turgan C., Caglar S., Prediction of renal allograft function with early Doppler ultrasonography, Transplant Proc, 36, 5, pp. 1348-1351, (2004)

← 1 2 3 →