Inflammatory cytokine gene polymorphisms in gastric cancer cases' and controls' family members from Chinese areas at high cancer prevalence

被引：22

作者：

Feng, Yunxia ^{[1
]}

Zhang, Jianzhong ^{[2
]}

Dai, Liping ^{[1
]}

Zhang, Jianying ^{[1
,3
]}

Wang, Peng ^{[1
]}

Zang, Jing ^{[1
]}

Li, Yuchun ^{[1
]}

Wang, Kaijuan ^{[1
,3
]}

机构：

[1] Zhengzhou Univ, Coll Publ Hlth, Dept Epidemiol, Zhengzhou 450001, Peoples R China

[2] China CDC, Inst Communicable Dis Control & Prevent, Beijing 102206, Peoples R China

[3] Univ Texas El Paso, Dept Biol Sci, El Paso, TX 79908 USA

来源：

CANCER LETTERS | 2008年 / 270卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Polymorphisms; IL-1; Gastric cancer; H; pylori; Haplotype analysis;

D O I：

10.1016/j.canlet.2008.05.013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The purpose of this study was to test the associations about Helicobacter pylori infection and polymorphisms of IL-1B-31/-511 and IL-1RN VNTR polymorphism with gastric cancer in cases' and controls' family members from the areas of high cancer prevalence in China. IL-1B-511T and IL-1RN*2 were associated with risks of gastric cancer. The association strength reduced with the relative degree decreasing. Such association was not found in the polymorphisms of IL-1B-31. But the haplotype analysis of IL-1B-511 and IL-1B-31 genotype could enhance the risks of gastric cancer. The positive H. pylori status could increase the risks of IL-1B to gastric cancer. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

收藏

页码：250 / 259

页数：10

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