共 53 条
Estimating the role of thymic output in HIV infection
被引:11
作者:

De Boer, Rob J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Utrecht, Utrecht, Netherlands Univ Utrecht, Utrecht, Netherlands
机构:
[1] Univ Utrecht, Utrecht, Netherlands
关键词:
depletion of naive T cells;
mathematical modeling;
thymus;
TRECs;
D O I:
10.1097/01.COH.0000194105.12816.6a
中图分类号:
R392 [医学免疫学];
Q939.91 [免疫学];
学科分类号:
100102 ;
摘要:
Purpose of review The mechanisms by which infection with CCR5 tropic HIV causes the depletion of naive CD4+ and CD8+ T cells are poorly understood. As HIV infection affects the thymus, one hypothesis is ` reduced thymic output'. As HIV infection is associated with hyperactivation, another hypothesis is ` depletion by activation'. The best technique that is currently available for measuring thymic output in humans is to quantify TCR excision circles (TRECs) in peripheral T cells. Unfortunately, TREC data are very difficult to interpret. Recent findings The depletion of memory CD4+ T cells can be accounted for by the massive infection of these cells in the gut and mucosal tissues. The major controversy therefore remains to explain the depletion of naive T cells. SIV infection of thymectomized and euthymic Rhesus macaques revealed important new insights into the effects of thymectomy and SIV infection on naive T cell depletion. Summary Changes in the TREC content, i.e. the average number of TRECs per cell, are confounded by changes in division rates. By also expressing TREC measurements in terms of total TREC numbers, one obtains a much more reliable indication of thymic production. The relatively rapid changes in TREC contents observed in subsets of HIV patients are best explained by changes in T cell division rates. Infection of the thymus is expected to play a role in the long-term depletion of naive T cells, but direct evidence remains scarce. Routinely measuring TREC totals, in addition to the TREC content and naive T cell counts, would help to finally sort this out.
引用
收藏
页码:16 / 21
页数:6
相关论文
共 53 条
[1]
Impact of thymectomy on the peripheral T cell pool in rhesus macaques before and after infection with simian immunodeficiency virus
[J].
Arron, ST
;
Ribeiro, RM
;
Gettie, A
;
Bohm, R
;
Blanchard, J
;
Yu, J
;
Perelson, AS
;
Hol, DD
;
Zhang, LQ
.
EUROPEAN JOURNAL OF IMMUNOLOGY,
2005, 35 (01)
:46-55

Arron, ST
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Ribeiro, RM
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Gettie, A
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Bohm, R
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Blanchard, J
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Yu, J
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Perelson, AS
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Hol, DD
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

Zhang, LQ
论文数: 0 引用数: 0
h-index: 0
机构: Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA
[2]
A central role for thymic emigrants in peripheral T cell homeostasis
[J].
Berzins, SP
;
Godfrey, DI
;
Miller, JFAP
;
Boyd, RL
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1999, 96 (17)
:9787-9791

Berzins, SP
论文数: 0 引用数: 0
h-index: 0
机构: Alfred Hosp, Monash Med Sch, Dept Pathol & Immunol, Prahran, Vic 3181, Australia

Godfrey, DI
论文数: 0 引用数: 0
h-index: 0
机构: Alfred Hosp, Monash Med Sch, Dept Pathol & Immunol, Prahran, Vic 3181, Australia

Miller, JFAP
论文数: 0 引用数: 0
h-index: 0
机构: Alfred Hosp, Monash Med Sch, Dept Pathol & Immunol, Prahran, Vic 3181, Australia

Boyd, RL
论文数: 0 引用数: 0
h-index: 0
机构: Alfred Hosp, Monash Med Sch, Dept Pathol & Immunol, Prahran, Vic 3181, Australia
[3]
Limited role for the thymus in SIV pathogenesis
[J].
Borghans, JAM
;
Hazenberg, MA
;
Miedema, F
.
EUROPEAN JOURNAL OF IMMUNOLOGY,
2005, 35 (01)
:42-45

Borghans, JAM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Utrecht, Ctr Med, Wilhemina Childrens Hosp, Dept Immunol, NL-3584 EA Utrecht, Netherlands

Hazenberg, MA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Utrecht, Ctr Med, Wilhemina Childrens Hosp, Dept Immunol, NL-3584 EA Utrecht, Netherlands

Miedema, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Utrecht, Ctr Med, Wilhemina Childrens Hosp, Dept Immunol, NL-3584 EA Utrecht, Netherlands
[4]
Continued maturation of thymic emigrants in the periphery
[J].
Boursalian, TE
;
Golob, J
;
Soper, DM
;
Cooper, CJ
;
Fink, PJ
.
NATURE IMMUNOLOGY,
2004, 5 (04)
:418-425

Boursalian, TE
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Immunol, Seattle, WA 98195 USA Univ Washington, Dept Immunol, Seattle, WA 98195 USA

Golob, J
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Immunol, Seattle, WA 98195 USA Univ Washington, Dept Immunol, Seattle, WA 98195 USA

Soper, DM
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Immunol, Seattle, WA 98195 USA Univ Washington, Dept Immunol, Seattle, WA 98195 USA

Cooper, CJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Immunol, Seattle, WA 98195 USA Univ Washington, Dept Immunol, Seattle, WA 98195 USA

Fink, PJ
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Washington, Dept Immunol, Seattle, WA 98195 USA Univ Washington, Dept Immunol, Seattle, WA 98195 USA
[5]
CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract
[J].
Brenchley, JM
;
Schacker, TW
;
Ruff, LE
;
Price, DA
;
Taylor, JH
;
Beilman, GJ
;
Nguyen, PL
;
Khoruts, A
;
Larson, M
;
Haase, AT
;
Douek, DC
.
JOURNAL OF EXPERIMENTAL MEDICINE,
2004, 200 (06)
:749-759

Brenchley, JM
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Schacker, TW
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Ruff, LE
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Price, DA
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Taylor, JH
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Beilman, GJ
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Nguyen, PL
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Khoruts, A
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Larson, M
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Haase, AT
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

Douek, DC
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Human Immunol Sect, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA
[6]
Exogenous IL-7 increases recent thymic emigrants in peripheral lymphoid tissue without enhanced thymic function
[J].
Chu, YW
;
Memon, SA
;
Sharrow, SO
;
Hakim, FT
;
Eckhaus, M
;
Lucas, PJ
;
Gress, RE
.
BLOOD,
2004, 104 (04)
:1110-1119

Chu, YW
论文数: 0 引用数: 0
h-index: 0
机构: NIH, Expt Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA

Memon, SA
论文数: 0 引用数: 0
h-index: 0
机构: NIH, Expt Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA

Sharrow, SO
论文数: 0 引用数: 0
h-index: 0
机构: NIH, Expt Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA

Hakim, FT
论文数: 0 引用数: 0
h-index: 0
机构: NIH, Expt Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA

Eckhaus, M
论文数: 0 引用数: 0
h-index: 0
机构: NIH, Expt Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA

Lucas, PJ
论文数: 0 引用数: 0
h-index: 0
机构: NIH, Expt Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA

Gress, RE
论文数: 0 引用数: 0
h-index: 0
机构: NIH, Expt Immunol Branch, Ctr Canc Res, Bethesda, MD 20892 USA
[7]
T cells containing T Cell receptor excision circles are inversely related to HIV replication and are selectively and rapidly released into circulation with antiretroviral treatment
[J].
Diaz, M
;
Douek, DC
;
Valdez, H
;
Hill, BJ
;
Petersond, D
;
Sanne, I
;
Piliero, PJ
;
Koup, RA
;
Green, SB
;
Schnittman, S
;
Lederman, MM
.
AIDS,
2003, 17 (08)
:1145-1149

Diaz, M
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Univ Hosp Cleveland, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

Douek, DC
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Univ Hosp Cleveland, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

Valdez, H
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Univ Hosp Cleveland, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

Hill, BJ
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Univ Hosp Cleveland, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

Petersond, D
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Univ Hosp Cleveland, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

Sanne, I
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Univ Hosp Cleveland, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

Piliero, PJ
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Univ Hosp Cleveland, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

Koup, RA
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Univ Hosp Cleveland, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

Green, SB
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Univ Hosp Cleveland, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

Schnittman, S
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Univ Hosp Cleveland, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

Lederman, MM
论文数: 0 引用数: 0
h-index: 0
机构: Case Western Reserve Univ, Univ Hosp Cleveland, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA
[8]
HIV infection rapidly induces and maintains a substantial suppression of thymocyte proliferation
[J].
Dion, ML
;
Poulin, JF
;
Bordi, R
;
Sylvestre, M
;
Corsini, R
;
Kettaf, N
;
Dalloul, A
;
Boulassel, MR
;
Debré, P
;
Routy, JP
;
Grossman, Z
;
Sékaly, RP
;
Cheynier, R
.
IMMUNITY,
2004, 21 (06)
:757-768

Dion, ML
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, CHUM, Immunol Lab, Ctr Rech, Montreal, PQ H2X 1P1, Canada

Poulin, JF
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, CHUM, Immunol Lab, Ctr Rech, Montreal, PQ H2X 1P1, Canada

Bordi, R
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, CHUM, Immunol Lab, Ctr Rech, Montreal, PQ H2X 1P1, Canada

Sylvestre, M
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, CHUM, Immunol Lab, Ctr Rech, Montreal, PQ H2X 1P1, Canada

Corsini, R
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, CHUM, Immunol Lab, Ctr Rech, Montreal, PQ H2X 1P1, Canada

Kettaf, N
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, CHUM, Immunol Lab, Ctr Rech, Montreal, PQ H2X 1P1, Canada

Dalloul, A
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, CHUM, Immunol Lab, Ctr Rech, Montreal, PQ H2X 1P1, Canada

Boulassel, MR
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, CHUM, Immunol Lab, Ctr Rech, Montreal, PQ H2X 1P1, Canada

Debré, P
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, CHUM, Immunol Lab, Ctr Rech, Montreal, PQ H2X 1P1, Canada

Routy, JP
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, CHUM, Immunol Lab, Ctr Rech, Montreal, PQ H2X 1P1, Canada

Grossman, Z
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, CHUM, Immunol Lab, Ctr Rech, Montreal, PQ H2X 1P1, Canada

Sékaly, RP
论文数: 0 引用数: 0
h-index: 0
机构:
Hop Hotel Dieu, CHUM, Immunol Lab, Ctr Rech, Montreal, PQ H2X 1P1, Canada Hop Hotel Dieu, CHUM, Immunol Lab, Ctr Rech, Montreal, PQ H2X 1P1, Canada

Cheynier, R
论文数: 0 引用数: 0
h-index: 0
机构: Hop Hotel Dieu, CHUM, Immunol Lab, Ctr Rech, Montreal, PQ H2X 1P1, Canada
[9]
Changes in thymic function with age and during the treatment of HIV infection
[J].
Douek, DC
;
McFarland, RD
;
Keiser, PH
;
Gage, EA
;
Massey, JM
;
Haynes, BF
;
Polis, MA
;
Haase, AT
;
Feinberg, MB
;
Sullivan, JL
;
Jamieson, BD
;
Zack, JA
;
Picker, LJ
;
Koup, RA
.
NATURE,
1998, 396 (6712)
:690-695

Douek, DC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75235 USA

McFarland, RD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75235 USA

Keiser, PH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75235 USA

Gage, EA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75235 USA

Massey, JM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75235 USA

Haynes, BF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75235 USA

Polis, MA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75235 USA

Haase, AT
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75235 USA

Feinberg, MB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75235 USA

Sullivan, JL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75235 USA

Jamieson, BD
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75235 USA

Zack, JA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75235 USA

Picker, LJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75235 USA

Koup, RA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Texas, SW Med Ctr, Dept Med, Dallas, TX 75235 USA
[10]
T cell dynamics in HIV-1 infection
[J].
Douek, DC
;
Picker, LJ
;
Koup, RA
.
ANNUAL REVIEW OF IMMUNOLOGY,
2003, 21
:265-304

Douek, DC
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Human Immunol Sect, NIH, Bethesda, MD 20892 USA

Picker, LJ
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Human Immunol Sect, NIH, Bethesda, MD 20892 USA

Koup, RA
论文数: 0 引用数: 0
h-index: 0
机构: NIAID, Human Immunol Sect, NIH, Bethesda, MD 20892 USA