Genetic characterization of respiratory syncytial viruses isolated from consecutive acute respiratory infections in a HIV infected child

被引:7
作者
Arbiza, J
Berois, M
Delfraro, A
Frabasile, S
Mitoma, FD
Milk, R
Russi, JC
机构
[1] Univ Republica, Fac Ciencias, Secc Virol, Montevideo 11400, Uruguay
[2] Minist Salud Publ, Dept Labs Salud Publ, Montevideo, Uruguay
[3] Childrens Hosp Eastern Ontario, Div Virol, Ottawa, ON K1H 8L1, Canada
关键词
HRSV; immunosuppressed child; genetic diversity;
D O I
10.1016/j.jcv.2005.03.009
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Background: Human respiratory syncytial virus (HRSV) was isolated from a 2-year-old child suffering from perinatally transmitted AIDS in the course of three distinct episodes of respiratory infections. The first episode Occurred in the winter of 1994, the following two episodes of cough and fever occurred two and 4 months after the initial episode. Objective: To analyze the genetic variability of the child's HRSV strains, and with contemporary circulating HRSV isolates. Results: The three child's HRSV isolates belonged to group B. Sequence analysis of the attachment (G) protein gene (which has the highest degree of antigenic and genetic diversity in HRSV), demonstrated no difference in the sequence obtained from the three isolates recovered from the child. Comparison of the child's HRSV strain with contemporary circulating group B HRSV isolates showed a close sequence similarity with one of them. Conclusions: The immunodeficiency in an HIV-positive child may have resulted in the recurrent isolation of one HRSV strain. Although it cannot be discarded the possibility that the recurrent episodes might be re-infections, it is unlikely in view of the lack of change in the HRSV glycoprotein G. This is the first study that analyzes the genetic variation in HRSV isolates from consecutive respiratory disease episodes in an immunosuppressed patient. (C) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:41 / 45
页数:5
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