Nidogen-1 Contributes to the Interaction Network Involved in Pro-B Cell Retention in the Peri-sinusoidal Hematopoietic Stem Cell Niche

被引：43

作者：

Balzano, Marielle ^{[1
,2
]}

De Grandis, Maria ^{[1
]}

Thien-Phong Vu Manh ^{[2
]}

Chasson, Lionel ^{[2
]}

Bardin, Florence ^{[1
]}

Farina, Anne ^{[3
,4
]}

Serge, Arnauld ^{[1
]}

Bidaut, Ghislain ^{[1
]}

Charbord, Pierre ^{[5
]}

Herault, Leonard ^{[1
,6
]}

Bailly, Anne-Laure ^{[1
]}

Cartier-Michaud, Amandine ^{[1
]}

Boned, Annie ^{[2
]}

Dalod, Marc ^{[2
]}

Duprez, Estelle ^{[1
]}

Genever, Paul ^{[7
]}

Coles, Mark ^{[8
]}

Bajenoff, Marc ^{[2
]}

Xerri, Luc ^{[9
]}

Aurrand-Lions, Michel ^{[1
]}

Schiff, Claudine ^{[2
]}

Mancini, Stephane J. C. ^{[1
,2
]}

机构：

[1] Aix Marseille Univ, CNRS, INSERM, Inst Paoli Calmettes,CRCM, Marseille, France

[2] Aix Marseille Univ, CNRS, INSERM, CIML, Marseille, France

[3] Aix Marseille Univ, ICEP Platform, INSERM, Inst Paoli Calmettes,CRCM, Marseille, France

[4] Aix Marseille Univ, MI Mabs, Marseille, France

[5] Sorbonne Univ, Inst Biol Paris Seine, Lab Biol Dev, Paris, France

[6] Aix Marseille Univ, CNRS, Cent Marseille, I2M, Marseille, France

[7] Univ York, Dept Biol, York YO10 5DD, N Yorkshire, England

[8] Univ Oxford, Kennedy Inst Rheumatol, Oxford OX3 7FY, England

[9] Aix Marseille Univ, Inst Paoli Calmettes, Dept Biopathol, Marseille, France

来源：

CELL REPORTS | 2019年 / 26卷 / 12期

关键词：

MARROW STROMAL CELLS; BONE-MARROW; DIFFERENTIATION; PROGENITORS; EXPRESSION; MAINTAIN; IDENTIFICATION; LYMPHOPOIESIS; MAINTENANCE; ADHESION;

D O I：

10.1016/j.celrep.2019.02.065

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

In the bone marrow, CXCL12 and IL-7 are essential for B cell differentiation, whereas hematopoietic stem cell (HSC) maintenance requires SCF and CXCL12. Peri-sinusoidal stromal (PSS) cells are the main source of IL-7, but their characterization as a pro-B cell niche remains limited. Here, we characterize pro-B cell supporting stromal cells and decipher the interaction network allowing pro-B cell retention. Preferential contacts are found between pro-B cells and PSS cells, which homogeneously express HSC and B cell niche genes. Furthermore, pro-B cells are frequently located in the vicinity of HSCs in the same niche. Using an interactome bioin-formatics pipeline, we identify Nidogen-1 as essential for pro-B cell retention in the peri-sinusoidal niche as confirmed in Nidogen-1 (-/- )mice. Finally, human pro-B cells and hematopoietic progenitors are observed close to similar IL-7(+) stromal cells. Thus, a multispecific niche exists in mouse and human supporting both early progenitors and committed hematopoietic lineages.

引用

页码：3257 / +

页数：23

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