Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics

被引：465

作者：

Ulrich, CM ^{[1
]}

Bigler, J ^{[1
]}

Potter, JD ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Seattle, WA 98109 USA

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 02期

关键词：

D O I：

10.1038/nrc1801

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aspirin and other non-steroidal anti-inflammatory drugs ( NSAIDs) show indisputable promise as chemopreventive agents. Possible targets include cancers of the colon, stomach, breast and lung. However, recent studies raise concern about potential cardiovascular toxicity associated with the use of NSAIDs that specifically target the enzyme cyclooxygenase 2. These findings, and others that show that inherited genetic characteristics might determine preventive success, argue for new strategies that are tailored to individual medical history and genetic make-up.

引用

页码：130 / 140

页数：11

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