How viruses enter animal cells

被引:597
作者
Smith, AE [1 ]
Helenius, A [1 ]
机构
[1] Swiss Fed Inst Technol, Inst Biochem, CH-8093 Zurich, Switzerland
关键词
D O I
10.1126/science.1094823
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Viruses replicate within living cells and use the cellular machinery for the synthesis of their genome and other components. To gain access, they have evolved a variety of elegant mechanisms to deliver their genes and accessory proteins into the host cell. Many animal viruses take advantage of endocytic pathways and rely on the cell to guide them through a complex entry and uncoating program. In the dialogue between the cell and the intruder, the cell provides critical cues that allow the virus to undergo molecular transformations that lead to successful internalization, intracellular transport, and uncoating.
引用
收藏
页码:237 / 242
页数:6
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