Promoter polymorphism in the candidate genes, IL-4, IL-9, TGF-β1, for atopy and asthma

被引：41

作者：

Rosenwasser, LJ ^{[1
]}

机构：

[1] Natl Jewish Med & Res Ctr, Div Clin Immunol & Allergy, Denver, CO 80206 USA

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1999年 / 118卷 / 2-4期

关键词：

cytokines; promoter polymorphisms; atopy; asthma;

D O I：

10.1159/000024096

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

This paper will review genetic variations in the structure of three important candidate genes with varying effects in atopy and asthma that may have significant overall susceptibility associations in relation to the development of atopy and asthma. The three cytokine genes involved are interleukin (IL)-4, IL-9 and transforming growth factor beta 1, and the nature of the polymorphisms may be related to significantly higher outputs of these cytokines in atopy and asthma.

引用

页码：268 / 270

页数：3

共 14 条

[1] TRANSFORMING GROWTH-FACTOR-BETA ABROGATES THE EFFECTS OF HEMATOPOIETINS ON EOSINOPHILS AND INDUCES THEIR APOPTOSIS
ALAM, R
FORSYTHE, P
STAFFORD, S
FUKUDA, Y
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1994, 179 (03) : 1041 - 1045
[2] TRANSFORMING GROWTH-FACTOR BETA(1) GENE-EXPRESSION IN HUMAN AIRWAYS
AUBERT, JD
DALAL, BI
BAI, TR
ROBERTS, CR
HAYASHI, S
HOGG, JC
[J]. THORAX, 1994, 49 (03) : 225 - 232
[3] SSC POLYMORPHISMS IN INTERLEUKIN GENES
BORISH, L
MASCALI, JJ
KLINNERT, M
LEPPERT, M
ROSENWASSER, LJ
[J]. HUMAN MOLECULAR GENETICS, 1994, 3 (09) : 1710 - 1710
[4] Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness
Doull, IJM
Lawrence, S
Watson, M
Begishvili, T
Beasley, RW
Lampe, F
Holgate, ST
Morton, NE
[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1996, 153 (04) : 1280 - 1284
[5] ASSOCIATION OF GLU-27 BETA(2)-ADRENOCEPTOR POLYMORPHISM WITH LOWER AIRWAY REACTIVITY IN ASTHMATIC SUBJECTS
HALL, IP
WHEATLEY, A
WILDING, P
LIGGETT, SB
[J]. LANCET, 1995, 345 (8959): : 1213 - 1214
[6] EVIDENCE FOR A LOCUS REGULATING TOTAL SERUM IGE LEVELS MAPPING TO CHROMOSOME-5
MEYERS, DA
POSTMA, DS
PANHUYSEN, CIM
XU, J
AMELUNG, PJ
LEVITT, RC
BLEECKER, ER
[J]. GENOMICS, 1994, 23 (02) : 464 - 470
[7] Interleukin 9: A candidate gene for asthma
Nicolaides, NC
Holroyd, KJ
Ewart, SL
Eleff, SM
Kiser, MB
Dragwa, CR
Sullivan, CD
Grasso, L
Zhang, LY
Messler, CJ
Zhou, TY
Kleeberger, SR
Buetow, KH
Levitt, RC
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (24) : 13175 - 13180
[8] EOSINOPHILS IN CHRONICALLY INFLAMED HUMAN UPPER AIRWAY TISSUES EXPRESS TRANSFORMING GROWTH FACTOR-BETA-1 GENE (TGF-BETA-1)
OHNO, I
LEA, RG
FLANDERS, KC
CLARK, DA
BANWATT, D
DOLOVICH, J
DENBURG, J
HARLEY, CB
GAULDIE, J
JORDANA, M
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1992, 89 (05) : 1662 - 1668
[9] LYMPHOCYTE-RESPONSES AND CYTOKINES
PAUL, WE
SEDER, RA
[J]. CELL, 1994, 76 (02) : 241 - 251
[10] GENETIC SUSCEPTIBILITY TO ASTHMA - BRONCHIAL, HYPERRESPONSIVENESS COINHERITED WITH A MAJOR GENE FOR ATOPY
POSTMA, DS
BLEECKER, ER
AMELUNG, PJ
HOLROYD, KJ
XU, JF
PANHUYSEN, CIM
MEYERS, DA
LEVITT, RC
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (14) : 894 - 900

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