Synthesis of enantiopure allylamines by reductive alkylation of amino epoxides with organolithium reagents

被引：17

作者：

Concellón, JM ^{[1
]}

Suárez, JR ^{[1
]}

del Solar, V ^{[1
]}

机构：

[1] Univ Oviedo, Fac Quim, Dept Quim Organ & Inorgan, E-33071 Oviedo, Spain

来源：

ORGANIC LETTERS | 2006年 / 8卷 / 02期

关键词：

D O I：

10.1021/ol0529602

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Transformation of enantiopure (2R,1'S)-2-(1-aminoalkyl)epoxides 1 into the corresponding allylamines 2 is described. The opening of the epoxide ring with different organolithium compounds takes place with total selectivity and in high yields.

引用

页码：349 / 351

页数：3

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