Prolinks: a database of protein functional linkages derived from coevolution

被引：210

作者：

Bowers, PM

Pellegrini, M

Thompson, MJ

Fierro, J

Yeates, TO

Eisenberg, D ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Inst Genom & Proteom, Los Angeles, CA 90095 USA

[2] 454 Corp, Branford, CT 06405 USA

来源：

GENOME BIOLOGY | 2004年 / 5卷 / 05期

关键词：

D O I：

10.1186/gb-2004-5-5-r35

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The advent of whole-genome sequencing has led to methods that infer protein function and linkages. We have combined four such algorithms (phylogenetic profile, Rosetta Stone, gene neighbor and gene cluster) in a single database-Prolinks-that spans 83 organisms and includes 10 million high-confidence links. The Proteome Navigator tool allows users to browse predicted linkage networks interactively, providing accompanying annotation from public databases. The Prolinks database and the Proteome Navigator tool are available for use online at http://dip.doe-mbi.ucla.edu/pronav.

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页数：13

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