Cytotoxic alkaloids from Houttuynia cordata

被引：93

作者：

Kim, SK ^{[1
]}

Ryu, SY ^{[1
]}

No, J ^{[1
]}

Choi, SU ^{[1
]}

Kim, YS ^{[1
]}

机构：

[1] Korea Res Inst Chem Technol, Taejon 305606, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2001年 / 24卷 / 06期

关键词：

Houttuynia cordata; cytotoxicity; alkaloids; aristololactams; 4,5-dioxoaporphine; oxoaporphin;

D O I：

10.1007/BF02975156

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Six bioactive alkaloids, aristolactam B(1), piperolactam A(2), aristolactam A(3), norcepharadione B(4), cepharadione B(5) and splendidine(6) were isolated by bioactivity-guided fractionation of a methanolic extract of the aerial part of Houttuynia cordata. Several of them exhibited significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15) in vitro.

引用

页码：518 / 521

页数：4

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