YAP and TAZ: a nexus for Hippo signaling and beyond

被引：609

作者：

Hansen, Carsten Gram ^{[1
,2
]}

Moroishi, Toshiro ^{[1
,2
]}

Guan, Kun-Liang ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Moores Canc Ctr, La Jolla, CA 92093 USA

来源：

TRENDS IN CELL BIOLOGY | 2015年 / 25卷 / 09期

基金：

美国国家卫生研究院;

关键词：

extracellular matrix; stem cells; regeneration; primary cilia; Wnt; Notch; YES-ASSOCIATED PROTEIN; EMBRYONIC STEM-CELLS; TUMOR-SUPPRESSOR PATHWAY; MUSCLE SATELLITE CELLS; BREAST-CANCER CELLS; TGF-BETA; TISSUE-GROWTH; CONTACT INHIBITION; SELF-RENEWAL; TRANSCRIPTIONAL ACTIVATOR;

D O I：

10.1016/j.tcb.2015.05.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

The Hippo pathway is a potent regulator of cellular proliferation, differentiation, and tissue homeostasis. Here we review the regulatory mechanisms of the Hippo pathway and discuss the function of Yes-associated protein (YAP)/transcriptional coactivator with a PDZ-binding domain (TAZ), the prime mediators of the Hippo pathway, in stem cell biology and tissue regeneration. We highlight their activities in both the nucleus and the cytoplasm and discuss their role as a signaling nexus and integrator of several other prominent signaling pathways such as the Wnt, G protein-coupled receptor (GPCR), epidermal growth factor (EGF), bone morphogenetic protein (BMP)/transforming growth factor beta (TGF beta), and Notch pathways.

引用

页码：499 / 513

页数：15

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