Loss of Ref-1 protein expression precedes DNA fragmentation in apoptotic neurons

被引：63

作者：

Walton, M

Lawlor, P

Sirimanne, E

Williams, C

Gluckman, P

Dragunow, M

机构：

[1] UNIV AUCKLAND,FAC MED & HLTH SCI,DEPT PHARMACOL & CLIN PHARMACOL,AUCKLAND 1,NEW ZEALAND

[2] UNIV AUCKLAND,FAC MED & HLTH SCI,RES CTR DEV MED & BIOL,AUCKLAND 1,NEW ZEALAND

来源：

MOLECULAR BRAIN RESEARCH | 1997年 / 44卷 / 01期

关键词：

Ref-1; c-Jun; hypoxia-ischemia; programmed cell death; apoptosis;

D O I：

10.1016/S0169-328X(96)00291-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Ref-1 is a bifunctional protein that has been implicated in the transcriptional regulation of AP-1 elements and in DNA. repair. To investigate whether Ref-1 is involved in programmed cell death its expression was measured in the 21-day-old rat brain at various time-points following a moderate unilateral hypoxic-ischemic (HI) insult. The CA1 pyramidal cells, which are selectively vulnerable to HT injury, showed a significant decrease in Ref-1 immunoreactivity 48 h-7 days post-insult. This loss of Ref-1 immunoreactivity may contribute to a decrease in endogenous repair activity and the development of apoptosis in the CAI pyramidal cells.

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收藏

页码：167 / 170

页数：4

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