Synthesis and biological evaluation of a new class of vaccine adjuvants: Aminoalkyl glucosaminide 4-phosphates (AGPs)

被引：64

作者：

Johnson, DA ^{[1
]}

Sowell, CG ^{[1
]}

Johnson, CL ^{[1
]}

Livesay, MT ^{[1
]}

Keegan, DS ^{[1
]}

Rhodes, MJ ^{[1
]}

Ulrich, JT ^{[1
]}

Ward, JR ^{[1
]}

Cantrell, JL ^{[1
]}

Brookshire, VG ^{[1
]}

机构：

[1] RIBI Immunochem Res Inc, Pharmaceut Discovery Div, Hamilton, MT 59840 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 15期

关键词：

D O I：

10.1016/S0960-894X(99)00374-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of acylated omega-aminoalkyl 2-amino-2-deoxy-4-phosphono-beta-D-glucopyranosides (aminoalkyl glucosaminide 4-phosphates) was synthesized and screened for immunostimulant activity. Several of these compounds enhance the production of tetanus toroid-specific antibodies in mice and augment vaccine-induced cytotoxic T cells against EG.7-ova target cells. (C) 1999 Elsevier Science Ltd. Pill rights reserved.

引用

页码：2273 / 2278

页数：6

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