Cytotoxic constituents of ethyl acetate fraction from Dianthus superbus

被引：37

作者：

Ding, Chengli ^{[1
]}

Zhang, Wu ^{[1
]}

Li, Jie ^{[1
]}

Lei, Jiachuan ^{[2
]}

Yu, Jianqing ^{[1
]}

机构：

[1] Wuhan Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Peoples R China

[2] Wuhan Univ, Renmin Hosp, Wuhan 430060, Peoples R China

来源：

NATURAL PRODUCT RESEARCH | 2013年 / 27卷 / 18期

基金：

中国国家自然科学基金;

关键词：

chemical constituent; Dianthus superbus; cytotoxicity; CYCLIC-PEPTIDES; APOPTOSIS;

D O I：

10.1080/14786419.2012.763127

中图分类号：

O69 [应用化学];

学科分类号：

070301 [无机化学];

摘要：

The ethyl acetate fraction (EE-DS) from Dianthus superbus was found to possess the cytotoxic activity against cancer cells in previous study. To investigate cytotoxic constituents, the bioassay-guided isolation of compounds from EE-DS was performed. Two dianthramides (1 and 2), three flavonoids (3-5), two coumarins (6 and 7) and three other compounds (8-10) were obtained. Structures of isolated compounds were identified by spectroscopic analysis. Cytotoxicity of the compounds against HepG2 cells was evaluated. Compound 1 showed the strongest cytotoxicity, compounds 10, 4, 3 and 5 had moderate cytotoxicity.

引用

页码：1691 / 1694

页数：4

共 7 条

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