Botulinum toxin in the treatment of neurological disorders of the autonomic nervous system

被引：47

作者：

Naumann, M

Jost, WH

Toyka, KV

机构：

[1] Univ Wurzburg, Neurol Klin, Dept Neurol, D-97080 Wurzburg, Germany

[2] Deutsch Klin Diagnost, D-6200 Wiesbaden, Germany

来源：

ARCHIVES OF NEUROLOGY | 1999年 / 56卷 / 08期

关键词：

D O I：

10.1001/archneur.56.8.914

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Botulinum neurotoxin A (BoNT/A) has become a valuable tool in the treatment of neurological disorders associated with increased muscle tone and has revolutionized the treatment of dystonia and focal spasticity. It acts at cholinergic nerve terminals by cleaving SNAP-25, a protein involved in the fusion of synaptic vesicles with the presynaptic membrane.(1) Cholinergic autonomic parasympathetic and postganglionic sympathetic nerve synapses are also amenable to treatment with botulinum toxin.

引用

页码：914 / 916

页数：3

共 12 条

[1]

Bergmann I, 1998, MUSCLE NERVE, V21, P1790, DOI 10.1002/(SICI)1097-4598(199812)21:12<1790::AID-MUS26>3.0.CO

[2]

2-I

[3] BOTULINUM NEUROTOXIN-A SELECTIVELY CLEAVES THE SYNAPTIC PROTEIN SNAP-25 [J].