Aging, the brain and human prion disease

被引：12

作者：

Kovács, GG ^{[1
]}

Budka, H ^{[1
]}

机构：

[1] Univ Vienna, Inst Neurol, Austrian Reference Ctr Human Pr Dis, A-1097 Vienna, Austria

来源：

EXPERIMENTAL GERONTOLOGY | 2002年 / 37卷 / 04期

关键词：

human prion disease; brain amyloidosis; prion protein;

D O I：

10.1016/S0531-5565(01)00219-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Human prion diseases (PrD) preferentially manifest in the elderly. Their neuropathology may coexist with tau immunoreactive neuropil threads, neurofibrillary tangles, and beta-amyloid senile plaques, most likely representing an age-related change rather than a pathogenic link with Alzheimer's disease. Cerebrovascular disease with brain infarction, another malady preferring the elderly, is useful to prove the origin of PrD-associated prion protein deposition exclusively from neurons. (C) 2002 Elsevier Science Inc. All rights reserved.

引用

页码：603 / 605

页数：3

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