Differential effects of aging on NADPH-diaphorase and VIP neurons in cerebral cortex of rats

被引：13

作者：

Huh, Y ^{[1
]}

Kim, C ^{[1
]}

Cho, J ^{[1
]}

Lee, W ^{[1
]}

Kim, J ^{[1
]}

Ahn, H ^{[1
]}

机构：

[1] NATL INST TOXICOL RES,LAB ANIM RESOURCES,SEOUL,SOUTH KOREA

来源：

NEUROREPORT | 1997年 / 8卷 / 13期

关键词：

aged rat; cerebral cortex; NADPH-diaphorase; vasoactive intestinal polypeptide;

D O I：

10.1097/00001756-199709080-00036

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

AGE-RELATED changes of NADPH-diaphorase (NADPH-d) and vasoactive intestinal polypeptide (VIP) were examined in the rat brain. Aged (24 months) rats showed a significant decrease in the number of VIP-immunoreactive (IR) neurons in the cerebral cortex when compared with control (4 months) rats. However, the number of NADPH-d-positive neurons was not significantly different in the two groups. Quantitative analysis of cell areas revealed a significant shrinkage of VIP-IR neurons in the aged group, whereas no further cell shrinkage was noted for NADPH-d-positive neurons compared with the control group. These morphometric results demonstrate that NADPH-d-containing neurons are more resistant to aging than the VIP-IR neurons in the cerebral cortex of rats.

引用

页码：2991 / 2994

页数：4

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