Presynaptic unsilencing: Searching for a mechanism

被引:5
作者
Atasoy, D [1 ]
Kavalali, ET [1 ]
机构
[1] Univ Texas, SW Med Ctr, Ctr Basic Neurosci, Dallas, TX 75390 USA
关键词
D O I
10.1016/j.neuron.2006.04.018
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Nascent synaptic networks have a high incidence of silent synapses. In this issue of Neuron, Shen et al. show that a brief burst of action potentials rapidly awaken silent synapses by increasing the availability of synaptic vesicles for fusion through BDNF-triggered presynaptic actin remodeling mediated by the small GTPase Cdc42.
引用
收藏
页码:345 / 346
页数:2
相关论文
共 10 条
[1]   Long-term potentiation of exogenous glutamate responses at single dendritic spines [J].
Bagal, AA ;
Kao, JPY ;
Tang, CM ;
Thompson, SM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (40) :14434-14439
[2]   Fusion pore modulation as a presynaptic mechanism contributing to expression of long-term potentiation [J].
Choi, S ;
Klingauf, J ;
Tsien, RW .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES, 2003, 358 (1432) :695-705
[3]   Assembly of new individual excitatory synapses: Time course and temporal order of synaptic molecule recruitment [J].
Friedman, HV ;
Bresler, T ;
Garner, CC ;
Ziv, NE .
NEURON, 2000, 27 (01) :57-69
[4]   Extrasynaptic glutamate spillover in the hippocampus: evidence and implications [J].
Kullmann, DM ;
Asztely, F .
TRENDS IN NEUROSCIENCES, 1998, 21 (01) :8-14
[5]   AMPA receptor trafficking and synaptic plasticity [J].
Malinow, R ;
Malenka, RC .
ANNUAL REVIEW OF NEUROSCIENCE, 2002, 25 :103-126
[6]   Development of vesicle pools during maturation of hippocampal synapses [J].
Mozhayeva, MG ;
Sara, Y ;
Liu, XR ;
Kavalali, ET .
JOURNAL OF NEUROSCIENCE, 2002, 22 (03) :654-665
[7]   A developmental switch in neurotransmitter flux enhances synaptic efficacy by affecting AMPA receptor activation [J].
Renger, JJ ;
Egles, C ;
Liu, GS .
NEURON, 2001, 29 (02) :469-484
[8]   Maturation of a central glutamatergic synapse [J].
Wu, GY ;
Malinow, R ;
Cline, HT .
SCIENCE, 1996, 274 (5289) :972-976
[9]   Assembling the presynaptic active zone: A characterization of an active zone precursor vesicle [J].
Zhai, RG ;
Vardinon-Friedman, H ;
Cases-Langhoff, C ;
Becker, B ;
Gundelfinger, ED ;
Ziv, NE ;
Garner, CC .
NEURON, 2001, 29 (01) :131-143
[10]   Stages of synapse development defined by dependence on F-actin [J].
Zhang, WD ;
Benson, DL .
JOURNAL OF NEUROSCIENCE, 2001, 21 (14) :5169-5181