Cell cycle control of yeast filamentous growth

被引：82

作者：

Rua, D

Tobe, BT

Kron, SJ ^{[1
]}

机构：

[1] Univ Chicago, Ctr Mol Oncol, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Mol Genet & Cell Biol, Chicago, IL 60637 USA

[3] Univ Chicago, Comm Canc Biol, Chicago, IL 60637 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2001年 / 4卷 / 06期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S1369-5274(01)00274-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Great progress has been made toward dissecting the signal transduction pathways and transcriptional outputs regulating yeast pseudohyphal growth. However, the mechanism underlying polarized morphogenesis in filamentous growth remains unclear. A synthesis of the data suggests that the ultimate target of these pathways is to repress the activity of the mitotic cyclin Clb2 as an antagonist of polarized growth. Here, we discuss how this cell cycle regulation, in concert with control of transcription, ubiquitin-dependent proteolysis and cytoskeletal polarity, may mediate the switch to filamentous growth.

引用

收藏

页码：720 / 727

页数：8

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