Biomimetic coating on bioactive glass-derived scaffolds mimicking bone tissue

被引：43

作者：

Bellucci, D. ^{[1
]}

Sola, A. ^{[1
]}

Gentile, P. ^{[2
]}

Ciardelli, G. ^{[2
,3
]}

Cannillo, V. ^{[1
]}

机构：

[1] Univ Modena & Reggio Emilia, Dept Mat & Environm Engn, I-41125 Modena, Italy

[2] Politecn Torino, Dept Mech & Aerosp Engn, I-10129 Turin, Italy

[3] CNR IPCF UOS Pisa, I-56124 Pisa, Italy

来源：

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | 2012年 / 100A卷 / 12期

关键词：

bone tissue engineering; scaffold; genipin; gelatin; bioactive glass; CROSS-LINKING AGENT; OF-THE-ART; IN-VITRO; GENIPIN; APATITE; REGENERATION; GELATIN; RAMAN; CHITOSAN; POROSITY;

D O I：

10.1002/jbm.a.34271

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Bioceramic shell scaffolds, with a morphology resembling the cancellous bone microstructure, have been recently obtained by means of a new protocol, developed with the aim to overcome the limits of the conventional foam replication technique. Because of their original microstructure, the new samples combine high porosity, permeability, and manageability. In this study, for the first time, the novel bioactive glass shell scaffolds are provided with a gelatin-based biomimetic coating to realize hybrid implants which mimic the complex morphology and structure of bone tissue. Moreover, the presence of the coating completely preserves the in vitro bioactivity of the bioactive glass samples, whose surfaces are converted into hydroxyapatite after a few days of immersion in a simulated body fluid solution (SBF). (c) 2012 Wiley Periodicals, Inc. J Biomed Mater Res Part A 100A:32513258, 2012.

引用

页码：3259 / 3266

页数：8

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