Preparation of polymer-bound 1H-benzotriazole, a new potential scaffold for the compilation of organic molecule libraries

被引：24

作者：

Katritzky, AR ^{[1
]}

Belyakov, SA

Tymoshenko, DO

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Cpds, Gainesville, FL 32611 USA

[2] Guillford Pharmaceut, Baltimore, MD 21224 USA

来源：

JOURNAL OF COMBINATORIAL CHEMISTRY | 1999年 / 1卷 / 02期

关键词：

D O I：

10.1021/cc980034r

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient method for the preparation of polymer-bound 1H-benzotriazole has been devised. The reaction of Merrifield resin with sodium 3-nitro-4-aminophenolate and the subsequent reduction and reaction with isoamyl nitrite afforded benzotriazole preloaded resin. A series of tertiary amines and a tosylamide were prepared using solid-phase benzotriatole-mediated transformations.

引用

页码：173 / 176

页数：4

共 6 条

[1] HOBT immobilized on macroporous polystyrene beads: a useful reagent for the synthesis of amides [J].

Dendrinos, K ;

Jeong, J ;

Huang, W ;

Kalivretenos, AG .

CHEMICAL COMMUNICATIONS, 1998, (04) :499-500

[2] Synthesis of N-hydroxysuccinimide esters using polymer bound HOBT. [J].

Dendrinos, KG ;

Kalivretenos, AG .

TETRAHEDRON LETTERS, 1998, 39 (11) :1321-1324

[3] NEW USEFUL REAGENTS FOR PEPTIDE-SYNTHESIS - INSOLUBLE ACTIVE ESTERS OF POLYSTYRENE-BOUND 1-HYDROXYBENZOTRIAZOLE [J].

KALIR, R ;

WARSHAWSKY, A ;

FRIDKIN, M ;

PATCHORNIK, A .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1975, 59 (01) :55-61

[4] Properties and synthetic utility of N-substituted benzotriazoles [J].

Katritzky, AR ;

Lan, XF ;

Yang, JZ ;

Denisko, OV .

CHEMICAL REVIEWS, 1998, 98 (02) :409-548

[5]

Katritzky AR, 1998, ALDRICHIM ACTA, V31, P35

[6] Versatile acylation of N-nucleophiles using a new polymer-supported 1-hydroxybenzotriazole derivative [J].

Pop, IE ;

Deprez, BP ;

Tartar, AL .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (08) :2594-2603

← 1 →