Conditional deletion of Xist disrupts histone macroH2A localization but not maintenance of X inactivation

被引:283
作者
Csankovszki, G
Panning, B
Bates, B
Pehrson, JR
Jaenisch, R [1 ]
机构
[1] MIT, Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
[2] MIT, Dept Biol, Cambridge, MA 02142 USA
[3] Univ Penn, Sch Vet Med, Dept Biol Anim, Philadelphia, PA 19104 USA
关键词
D O I
10.1038/11887
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
引用
收藏
页码:323 / 324
页数:2
相关论文
共 15 条
[1]   SITE-SPECIFIC RECOMBINATION MEDIATED BY AN ADENOVIRUS VECTOR EXPRESSING THE CRE RECOMBINASE PROTEIN - A MOLECULAR SWITCH FOR CONTROL OF GENE-EXPRESSION [J].
ANTON, M ;
GRAHAM, FL .
JOURNAL OF VIROLOGY, 1995, 69 (08) :4600-4606
[2]   CHARACTERIZATION OF A MURINE GENE EXPRESSED FROM THE INACTIVE X-CHROMOSOME [J].
BORSANI, G ;
TONLORENZI, R ;
SIMMLER, MC ;
DANDOLO, L ;
ARNAUD, D ;
CAPRA, V ;
GROMPE, M ;
PIZZUTI, A ;
MUZNY, D ;
LAWRENCE, C ;
WILLARD, HF ;
AVNER, P ;
BALLABIO, A .
NATURE, 1991, 351 (6324) :325-329
[3]   CONSERVATION OF POSITION AND EXCLUSIVE EXPRESSION OF MOUSE XIST FROM THE INACTIVE X-CHROMOSOME [J].
BROCKDORFF, N ;
ASHWORTH, A ;
KAY, GF ;
COOPER, P ;
SMITH, S ;
MCCABE, VM ;
NORRIS, DP ;
PENNY, GD ;
PATEL, D ;
RASTAN, S .
NATURE, 1991, 351 (6324) :329-331
[4]   THE PRODUCT OF THE MOUSE XIST GENE IS A 15 KB INACTIVE X-SPECIFIC TRANSCRIPT CONTAINING NO CONSERVED ORF AND LOCATED IN THE NUCLEUS [J].
BROCKDORFF, N ;
ASHWORTH, A ;
KAY, GF ;
MCCABE, VM ;
NORRIS, DP ;
COOPER, PJ ;
SWIFT, S ;
RASTAN, S .
CELL, 1992, 71 (03) :515-526
[5]   THE HUMAN X-INACTIVATION CENTER IS NOT REQUIRED FOR MAINTENANCE OF X-CHROMOSOME INACTIVATION [J].
BROWN, CJ ;
WILLARD, HF .
NATURE, 1994, 368 (6467) :154-156
[6]   XIST RNA paints the inactive X chromosome at interphase: Evidence for a novel RNA involved in nuclear chromosome structure [J].
Clemson, CM ;
McNeil, JA ;
Willard, HF ;
Lawrence, JB .
JOURNAL OF CELL BIOLOGY, 1996, 132 (03) :259-275
[7]   Histone macroH2A1 is concentrated in the inactive X chromosome of female mammals [J].
Costanzi, C ;
Pehrson, JR .
NATURE, 1998, 393 (6685) :599-601
[8]   Reactivation of XIST in normal fibroblasts and a somatic cell hybrid:: Abnormal localization of XIST RNA in hybrid cells [J].
Hansen, RS ;
Canfield, TK ;
Stanek, AM ;
Keitges, EA ;
Gartler, SM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (09) :5133-5138
[9]   THE INACTIVE X-CHROMOSOME IN FEMALE MAMMALS IS DISTINGUISHED BY A LACK OF HISTONE-H4 ACETYLATION, A CYTOGENETIC MARKER FOR GENE-EXPRESSION [J].
JEPPESEN, P ;
TURNER, BM .
CELL, 1993, 74 (02) :281-289
[10]   Role of the Xist gene in X chromosome choosing [J].
Marahrens, Y ;
Loring, J ;
Jaenisch, R .
CELL, 1998, 92 (05) :657-664