Regulation of the phosphodiesterase PDE4B3-isotype during long-term potentiation in the area dentata in vivo

被引：17

作者：

Ahmed, T ^{[1
]}

Frey, S ^{[1
]}

Frey, JU ^{[1
]}

机构：

[1] Dept Neurophysiol, Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany

来源：

NEUROSCIENCE | 2004年 / 124卷 / 04期

关键词：

long-term potentiation; area dentata; phosphodiesterase PDE4B3; memory formation; learning; hippocampus;

D O I：

10.1016/j.neuroscience.2004.01.005

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hippocampal long-term potentiation (LTP) is the most prominent cellular model underlying learning and memory formation. However, which cellular processes are involved in maintaining LTP remains largely unknown. We have previously detailed temporal modulations of cyclic adenosine monophosphate (cAMP) and a cAMP-specific phosphodiesterase, PDE4B3, after LTP-induction and its maintenance in hippocampal area CA1 in vitro. To test whether other hippocampal sub-structures are characterised by similar mechanisms, tissue from the area dentata of freely moving rats was analysed at different LTP-time points. The tissue was fractionated into three components, where PDE4B-levels and cAMP-concentrations were measured. In contrast with data obtained in area CA1 [Neuroscience 1117 (2003) 627], we now detail an LTP-specific translational, but not transcriptional regulation of PDE4B3 within the first 8 h after tetanization and present spatio-temporal changes of PDE4B proteins and cAMP that is LTP-specific. (C) 2004 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：857 / 867

页数：11

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