Iseganan hydrochloride - Treatment of mucositis - Treatment of cystic fibrosis - Antibiotic

Oral mucositis is a side effect often found in cancer patients treated-with high doses of chemotherapy and radiotherapy. Its painful lesions may be exacerbated by colonization by endogenous microflora and pathogens, which in turn may Cause systemic infections. Iseganan hydrochloride is a protegrin analog that binds to components of the bacterial cell surface, such as LPS and LTA, damaging the cell membranes and killing the bacteria through swelling and bursting. In vitro studies have shown iseganan to be effective against Gram-positive and Gram-negative bacteria, and experimental studies in hamsters demonstrated that the compound decreased the severity and duration of oral mucositis and improved the survival rate of animals. Iseganan was found to decrease the pain and severity of oral mucositis in patients undergoing myeloablative chemotherapy, and was also effective against other conditions such as ventilator-associated pneumonia.