Organelle degradation during the lens and erythroid differentiation is independent of autophagy

被引：94

作者：

Matsui, M

Yamamoto, A

Kuma, A

Ohsumi, Y

Mizushima, N ^{[1
]}

机构：

[1] Tokyo Metropolitan Inst Med Sci, Dept Bioregulat & Metab, Tokyo 1138613, Japan

[2] Grad Inst Adv Studies, Sch Life Sci, Dept Basic Biol, Okazaki, Aichi 4448585, Japan

[3] Natl Inst Basic Biol, Dept Cell Biol, Okazaki, Aichi 4448585, Japan

[4] Nagahama Inst Biosci & Technol, Dept Biosci, Nagahama 5260829, Japan

[5] Japan Sci & Technol Agcy, PRESTO, Kawaguchi 3320012, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2006年 / 339卷 / 02期

关键词：

autophagy; lens; erythroid cell; organelle degradation; lysosome;

D O I：

10.1016/j.bbrc.2005.11.044

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autophagy is a bulk degradation system within cells through which cytoplasmic components are degraded within lysosomes. Primary roles of autophagy are starvation adaptation and intracellular protein quality control. In contrast to the ubiquitin-proteasome system, autophagy can also degrade organelles. Here we examined a possible role of autophagy in organelle degradation during lens and erythroid differentiation. We observed that autophagy occurs in embryonic lens cells. However, organelle degradation in lens and erythroid cells occurred normally in autophagy-deficient Atg5(-/-) mice. Our data suggest that degradation system(s) other than autophagy play major roles in organelle degradation during these processes. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：485 / 489

页数：5

共 34 条

[1] Lens organelle degradation [J].