Data and safety monitoring in the Delta trial

被引：6

作者：

Armitage, P ^{[1
]}

机构：

[1] Univ Oxford, St Peters Coll, Oxford, England

来源：

CONTROLLED CLINICAL TRIALS | 1999年 / 20卷 / 03期

关键词：

AIDS trials; HIV infection; data and safety monitoring; interim analyses; survival data;

D O I：

10.1016/S0197-2456(99)00003-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Delta was a randomized trial designed to test whether combinations of zidovudine (AZT) with didanosine (ddI) or zalcitabine (ddC) were more effective than AZT alone for HIV-infected persons. A Data and Safety Monitoring Committee (DSMC) monitored accumulating data. This paper describes the deliberations and recommendations of the DSMC, as clear-cut differences in efficacy gradually emerged during the later stages of the trial. Control Clin Trials 1999;20:229-241 (C) Elsevier Science Inc., 1999.

引用

页码：229 / 241

页数：13

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