Global transcriptome analysis of Staphylococcus aureus response to hydrogen peroxide

被引：121

作者：

Chang, W

Small, DA

Toghrol, F ^{[1
]}

Bentley, WE

机构：

[1] US EPA, Microarray Res Lab, Biol & Econ Anal Div, Off Pesticide Programs, Ft George G Meade, MD 20755 USA

[2] Univ Maryland, Inst Biotechnol, Ctr Biosyst Res, College Pk, MD 20742 USA

来源：

JOURNAL OF BACTERIOLOGY | 2006年 / 188卷 / 04期

关键词：

D O I：

10.1128/JB.188.4.1648-1659.2006

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Staphylococcus aureus responds with protective strategies against phagocyte-derived reactive oxidants to infect humans. Herein, we report the transcriptome analysis of the cellular response of S. aureus to hydrogen peroxide-induced oxidative stress. The data indicate that the oxidative response includes the induction of genes involved in virulence, DNA repair, and notably, anaerobic metabolism.

引用

收藏

页码：1648 / 1659

页数：12

相关论文

共 63 条

[1] Effects of limited aeration and of the ArcAB system on intermediary pyruvate catabolism in Escherichia coli [J].

Alexeeva, S ;

de Kort, B ;

Sawers, G ;

Hellingwerf, KJ ;

de Mattos, MJT .

JOURNAL OF BACTERIOLOGY, 2000, 182 (17) :4934-4940

[2] Reconstitution of an SOS response pathway: Derepression of transcription in response to DNA breaks [J].

Anderson, DG ;

Kowalczykowski, SC .

CELL, 1998, 95 (07) :975-979

[3] A RecA-LexA-dependent pathway mediates ciprofloxacin-induced fibronectin binding in Staphylococcus aureus [J].

Bisognano, C ;

Kelley, WL ;

Estoppey, T ;

Francois, P ;

Schrenzel, J ;

Li, DM ;

Lew, DP ;

Hooper, DC ;

Cheung, AL ;

Vaudaux, P .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (10) :9064-9071

[4] The Staphylococcus aureus scdA gene: a novel locus that affects cell division and morphogenesis [J].

Brunskill, EW ;

deJonge, BLM ;

Bayles, KW .

MICROBIOLOGY-UK, 1997, 143 :2877-2882

[5] Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus [J].

Brunskill, EW ;

Bayles, KW .

JOURNAL OF BACTERIOLOGY, 1996, 178 (03) :611-618

[6] CORNEAL VIRULENCE OF STAPHYLOCOCCUS-AUREUS - ROLES OF ALPHA-TOXIN AND PROTEIN-A IN PATHOGENESIS [J].

CALLEGAN, MC ;

ENGEL, LS ;

HILL, JM ;

OCALLAGHAN, RJ .

INFECTION AND IMMUNITY, 1994, 62 (06) :2478-2482

[7] MICROBIAL GLYCOLIPIDS - POSSIBLE VIRULENCE FACTORS THAT SCAVENGE OXYGEN RADICALS [J].

CHAN, J ;

FUJIWARA, T ;

BRENNAN, P ;

MCNEIL, M ;

TURCO, SJ ;

SIBILLE, JC ;

SNAPPER, M ;

AISEN, P ;

BLOOM, BR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (07) :2453-2457

[8] LIPOARABINOMANNAN, A POSSIBLE VIRULENCE FACTOR INVOLVED IN PERSISTENCE OF MYCOBACTERIUM-TUBERCULOSIS WITHIN MACROPHAGES [J].

CHAN, J ;

FAN, X ;

HUNTER, SW ;

BRENNAN, PJ ;

BLOOM, BR .

INFECTION AND IMMUNITY, 1991, 59 (05) :1755-1761

[9] Microarray analysis of Pseudomonas aeruginosa reveals induction of pyocin genes in response to hydrogen peroxide -: art. no. 115 [J].

Chang, W ;

Small, DA ;

Toghrol, F ;

Bentley, WE .

BMC GENOMICS, 2005, 6 (1) :1-14

[10] Microarray analysis of toxicogenomic effects of peracetic acid on Pseudomonas aeruginosa [J].

Chang, W ;

Small, DA ;

Toghrol, F ;

Bentley, WE .

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2005, 39 (15) :5893-5899

← 1 2 3 4 5 6 7 →