Dissociation constants of water-insoluble carboxylic acids by C-13-NMR. PK(a)s of mesobiliverdin-XIII alpha and mesobilirubin-XIII alpha

被引：5

作者：

Lightner, DA

Holmes, DL

McDonagh, AF

机构：

[1] UNIV CALIF SAN FRANCISCO,DEPT MED,SAN FRANCISCO,CA 94143

[2] UNIV CALIF SAN FRANCISCO,CTR LIVER,SAN FRANCISCO,CA 94143

来源：

EXPERIENTIA | 1996年 / 52卷 / 06期

关键词：

bilirubin; biliverdin; dimethylsulfoxide; dicarboxylic acids;

D O I：

10.1007/BF01969747

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

High-field C-13-NMR of C-13-enriched compounds in dilute aqueous d(6)-Me(2)SO solutions provides a simple, accurate method for measuring pK(a)s of sparingly soluble carboxylic acids. Using this method, we found the pK(a)s of mesobilirubin-XIII alpha to be 4.2 and 4.9, much lower values than reported recently for bilirubin, and of mesobiliverdin-XIII alpha to be 3.9 and 5.3.

引用

页码：639 / 642

页数：4

共 30 条

[1] ABSOLUTE-CONFIGURATION OF BILIRUBIN CONFORMATIONAL ENANTIOMERS [J].

BOIADJIEV, SE ;

PERSON, RV ;

PUZICHA, G ;

KNOBLER, C ;

MAVERICK, E ;

TRUEBLOOD, KN ;

LIGHTNER, DA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (26) :10123-10133

[2] STRUCTURE OF BILIRUBIN [J].

BONNETT, R ;

DAVIES, JE ;

HURSTHOUSE, MB ;

SHELDRICK, GM .

PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1978, 202 (1147) :249-268

[3]

BRODERSEN R, 1986, BILE PIGMENTS JAUNDI, P158

[4]

CABRAL DP, 1986, J LIPID RES, V24, P334

[5]

CAREY MC, 1986, BILE PIGMENTS JAUNDI, P81

[6]

CISTOLA DP, 1982, J LIPID RES, V23, P795

[7]

Eberson L., 1969, The Chemistry of Carboxylic Acids and Esters, P211

[8]

Falk H., 1989, The Chemistry of Linear Oligopyrroles and Bile Pigments

[9] NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY - 13C SPECTRA OF ALIPHATIC CARBOXYLIC ACIDS AND CARBOXYLATE ANIONS [J].

HAGEN, R ;

ROBERTS, JD .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1969, 91 (16) :4504-&

[10]

HAHM JS, 1992, J LIPID RES, V33, P1123

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