Vitamin D: a negative acute phase reactant

被引：206

作者：

Waldron, Jenna Louise ^{[1
]}

Ashby, Helen L. ^{[1
]}

Cornes, Michael P. ^{[1
]}

Bechervaise, Julia ^{[1
]}

Razavi, Cyrus ^{[1
]}

Thomas, Osmond L. ^{[2
]}

Chugh, Sanjiv ^{[2
]}

Deshpande, Shreeram ^{[2
]}

Ford, Clare ^{[1
]}

Gama, Rousseau ^{[1
,3
]}

机构：

[1] New Cross Hosp, Dept Clin Chem, Wolverhampton WV10 0QP, W Midlands, England

[2] New Cross Hosp, Dept Orthopaed, Wolverhampton WV10 0QP, W Midlands, England

[3] Wolverhampton Univ, Res Inst, Dept Healthcare Sci, Wolverhampton WV1 1DJ, W Midlands, England

来源：

JOURNAL OF CLINICAL PATHOLOGY | 2013年 / 66卷 / 07期

关键词：

D DEFICIENCY;

D O I：

10.1136/jclinpath-2012-201301

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objective We evaluated the effect of the systemic inflammatory response (SIR), as provoked by elective orthopaedic surgery, on serum vitamin D [25-(OH) D]. Methods Serum 25-(OH) D, serum vitamin D binding protein (VDBP) and urinary VDBP were measured in 30 patients before and 48-hours after knee or hip arthroplasty. C-reactive protein (CRP) was measured to assess the SIR. Results The mean (SD) CRP increased following surgery [5.0 (5.5) vs 116.0 (81.2) mg/L; P<0.0001] as did urine VDBP/Creatinine ratio [8 (9) vs 20 (25) pg/mmol; p=0.0004]. Serum 25-(OH) D [56.2 (30.3) vs 46.0 (27.6) nmol/L; p = 0.0006] and serum VDBP [334 (43) vs 298 (37) mg/L]; P<0.0001] decreased. Conclusions Serum 25-(OH) D is a negative acute phase reactant, which has implications for acute and chronic inflammatory diseases. Serum 25-(OH) D is an unreliable biomarker of vitamin D status after acute inflammatory insult. Hypovitaminosis D may be the consequence rather than cause of chronic inflammatory diseases.

引用

页码：620 / 622

页数：3

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