Rapid Increase in the Prevalence of Sulfadoxine-Pyrimethamine Resistance among Plasmodium falciparum Isolated from Pregnant Women in Ghana

被引：51

作者：

Mockenhaupt, Frank P. ^{[1
]}

Bedu-Addo, George ^{[2
]}

Eggelte, Teunis A. ^{[4
]}

Hommerich, Lena ^{[1
]}

Holmberg, Ville ^{[1
,5
]}

von Oertzen, Christa ^{[3
]}

Bienzle, Ulrich ^{[1
]}

机构：

[1] Charite, Inst Topical Med & Int Hlth, D-14050 Berlin, Germany

[2] Kwame Nkrumah Univ Sci & Technol, Dept Med, Sch Med Sci, Kumasi, Ghana

[3] Presbyterian Mission Hosp, Agogo, Ghana

[4] Acad Med Ctr, Div Infect Dis Trop Med & AIDS, Amsterdam, Netherlands

[5] Univ Helsinki, Dept Bacteriol & Immunol, Haartman Inst, Helsinki, Finland

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 198卷 / 10期

关键词：

D O I：

10.1086/592455

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Use of intermittent preventive treatment with sulfadoxine-pyrimethamine (SP) during pregnancy (IPTp-SP) has become policy in much of sub-Saharan Africa but crucially depends on the efficacy of SP. We assessed the frequency of the dhfr triple mutation among Plasmodium falciparum isolates obtained from pregnant Ghanaian women in 1998, 2000, and 2006. The prevalence of the triple mutation, which confers resistance to SP, doubled from 36% to 73% during the study period (P<.001). In 2006, the prevalence was virtually identical among women of early gestation and delivering women with or without a history of IPTp-SP use, indicating that such treatment did not select for mutant parasites. Nevertheless, IPTp-SP may be outdated by drug resistance before it is fully implemented.

引用

页码：1545 / 1549

页数：5

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