Synthesis of new pyridazin-6-ones, pyridazin-6-imines, 4-pyridazinals, and pyridines

被引：30

作者：

Sayed, SM ^{[1
]}

Khalil, MA

Ahmed, MA

Raslan, MA

机构：

[1] Univ S Valley, Fac Sci, Dept Chem, Aswan 81528, Egypt

[2] Univ S Valley, Fac Sci, Dept Chem, Qena, Egypt

来源：

SYNTHETIC COMMUNICATIONS | 2002年 / 32卷 / 03期

关键词：

azo compounds; active methylene; hydrazonoyl chloride;

D O I：

10.1081/SCC-120002134

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Dimethyl-1-[3-methyl-(4H)-5-phenylimidazol[2,1-b]thiazol-2-yl]prop-2-enone 4 couples smoothly with benzenediazonium chloride to yield propanal 5 which is a key intermediate for the synthesis of pyridazinones 9-13, 16 and pyridazine-6-imine 8, 19. Pentadienonitrile 18 was converted into pyridine-3-carbonitrile 20 on refluxing in ethanolic sodium ethoxide solution. Pyrazole 24 was synthesized from the reaction of 5 with 1-chloro-2-phenylhydrazono propan-2-one 22.

引用

页码：481 / 495

页数：15

共 23 条

[1] THE REACTION OF BETA-AMINOENONES WITH SUBSTITUTED ACETONITRILES - REGIOSPECIFIC SYNTHESIS OF 2(1H)-PYRIDONES [J].