Minimizing contrast agent dose during intraarterial gadolinium-enhanced MR angiography: In vitro assessment

Purpose: To minimize contrast agent dosage for intra-arterial (LA) contrast-enhanced magnetic resonance angiography (CE-MRA) by examining the effects of encoding order (elliptical vs. sequential) and injection duration (100% to 30% of the acquisition time). Materials and Methods: Catheter-based IA gadolinium (Gd) injections were performed in an arterial flow phantom. Blood flow rates, injection rates, and injection durations were systematically varied. Signal-to-noise (SNR) measurements were obtained in the aorta, renal artery, and common iliac artery. Results: No significant SNR losses were observed for any of the vessels with 75% injection duration, or for the aorta and iliac artery with 50% injection duration. Excellent images of all vessels were obtained at 5M/b injection duration. There was no significant SNR difference between encoding schemes. Conclusion: Contrast agent dosage can be substantially reduced without loss of SNR by limiting injection to part of the imaging acquisition time.