Influence of l-rhamnosyl-d-glucosyl derivatives on properties and biological interaction of flavonoids

被引：67

作者：

Bellocco, Ersilia ^{[1
]}

Barreca, Davide ^{[1
]}

Lagana, Giuseppina ^{[1
]}

Leuzzi, Ugo ^{[1
]}

Tellone, Ester ^{[1
]}

Ficarra, Silvana ^{[1
]}

Kotyk, Arnost ^{[2
]}

Galtieri, Antonio ^{[1
]}

机构：

[1] Univ Messina, Dept Organ & Biol Chem, I-98166 Messina, Italy

[2] Acad Sci Czech Republ, Inst Physiol, Prague, Czech Republic

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2009年 / 321卷 / 1-2期

关键词：

Neohesperidose; Rutinose; Hep G2; Anti-proliferative; Apoptosis; CELL-CYCLE ARREST; CANCER-CELLS; HEP G2; INDUCTION; APIGENIN; APOPTOSIS; GROWTH; INHIBITION; ACTIVATION; PROLIFERATION;

D O I：

10.1007/s11010-008-9930-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The anti-proliferative activity of hesperetin, hesperidin, neohesperidin and rutin was evaluated on human hepatoma cell lines (Hep G2) and correlated to their antioxidant activity. The results obtained showed strong anti-proliferative effects of hesperidin and neohesperidin, considerably higher than the other two additives. Hesperetin induced caspase-3 activation, release of LDH and endogenous accumulation of putrescine. Cell cycle distribution seems to indicate that the inhibitory effects of polyphenols on cell growth could be due to G0/G1 block, and activation of apoptotic pathway in the presence of hesperetin. Our results underline also that the glycone forms show reduced scavenging activity against DPPH, but present a remarkable inhibition of cell proliferation and low cytotoxicity.

引用

页码：165 / 171

页数：7

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