The role of microRNA in the response to cisplatin treatment

被引:26
作者
Drayton, Ross M. [1 ]
机构
[1] Univ Sheffield, Sch Med, Inst Canc Studies, Sheffield S10 2RX, S Yorkshire, England
关键词
cisplatin; microRNA (miRNA); protein expression; tumour; OVARIAN-CANCER CELLS; MODULATES MULTIDRUG-RESISTANCE; TARGETING BCL2; LUNG-CANCER; POLYMERASE-II; UP-REGULATION; EXPRESSION; RNA; CARCINOMA; SURVIVAL;
D O I
10.1042/BST20120055
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
070307 [化学生物学]; 071010 [生物化学与分子生物学];
摘要
Resistance to the cytotoxic effects of cisplatin can be mediated through changes in a wide variety of cellular processes and signalling pathways. The discovery of microRNAs as regulators of protein expression through the targeting of mRNA has led to a number of studies on the effect of cisplatin treatment on microRNA expression, and the ability of microRNAs to modulate cisplatin resistance.
引用
收藏
页码:821 / 825
页数:5
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