共 53 条
The role of microRNA in the response to cisplatin treatment
被引:26
作者:

Drayton, Ross M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Sheffield, Sch Med, Inst Canc Studies, Sheffield S10 2RX, S Yorkshire, England Univ Sheffield, Sch Med, Inst Canc Studies, Sheffield S10 2RX, S Yorkshire, England
机构:
[1] Univ Sheffield, Sch Med, Inst Canc Studies, Sheffield S10 2RX, S Yorkshire, England
关键词:
cisplatin;
microRNA (miRNA);
protein expression;
tumour;
OVARIAN-CANCER CELLS;
MODULATES MULTIDRUG-RESISTANCE;
TARGETING BCL2;
LUNG-CANCER;
POLYMERASE-II;
UP-REGULATION;
EXPRESSION;
RNA;
CARCINOMA;
SURVIVAL;
D O I:
10.1042/BST20120055
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
070307 [化学生物学];
071010 [生物化学与分子生物学];
摘要:
Resistance to the cytotoxic effects of cisplatin can be mediated through changes in a wide variety of cellular processes and signalling pathways. The discovery of microRNAs as regulators of protein expression through the targeting of mRNA has led to a number of studies on the effect of cisplatin treatment on microRNA expression, and the ability of microRNAs to modulate cisplatin resistance.
引用
收藏
页码:821 / 825
页数:5
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