Synthesis of a water-soluble fullerene derivative nanoball and its biological activity

被引：11

作者：

Jiang, GC ^{[1
]}

Zheng, QX

Yang, DZ

机构：

[1] Huazhong Univ Sci & Technol, Dept Biol, Wuhan 430074, Peoples R China

[2] Huainan Teachers Coll, Dept Chem, Anhui 232001, Peoples R China

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2006年 / 99卷 / 06期

关键词：

copolymer; water solubility; biological activity; fullerene; mechanism;

D O I：

10.1002/app.22837

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

A novel fullerene-acrylamide copolymer was synthesized via radical polymerization. It is soluble in polar solvents such as water and dimethyl sulfoxide. The product was characterized by FTIR, UV-vis, and GPC. TEM analysis showed that the average particle diameter was about 46 nm. The in vitro antitumor activity of the fullerene-acrylamide derivatives was tested, and the results showed that the novel fullerene-acrylamide derivatives exhibited better antitumor activity in vitro against bone tumor cells. The cytotoxicity against the tumor cell mechanism of the fullerene copolymer nanoball was studied. (c) 2005 Wiley Periodicals, Inc.

引用

页码：2874 / 2877

页数：4

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