Signalling to actin: the Cdc42-N-WASP-Arp2/3 connection

被引：67

作者：

Carlier, MF ^{[1
]}

Ducruix, A ^{[1
]}

Pantaloni, D ^{[1
]}

机构：

[1] CNRS, Lab Enzymol & Biochim Struct, F-75270 Paris, France

来源：

CHEMISTRY & BIOLOGY | 1999年 / 6卷 / 09期

关键词：

D O I：

10.1016/S1074-5521(99)80107-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The molecular link between the signalling pathway regulating the formation of filopodia and the initiation of local actin polymerization has been elucidated: N-WASP, a close homologue of WASP, which is the product of the gene responsible for the Wiskott-Aldrich syndrome, mediates a direct connection between the small G-protein Cdc42 and the Arp2/3 complex.

引用

页码：R235 / R240

页数：6

共 28 条

[1] Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein [J].

Abdul-Manan, N ;

Aghazadeh, B ;

Liu, GA ;

Majumdar, A ;

Ouerfelli, O ;

Siminovitch, KA ;

Rosen, MK .

NATURE, 1999, 399 (6734) :379-383

[2] Two GTPases, cdc42 and rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome [J].

Aspenstrom, P ;

Lindberg, U ;

Hall, A .

CURRENT BIOLOGY, 1996, 6 (01) :70-75

[3] SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development [J].

Bear, JE ;

Rawls, JF ;

Saxe, CL .

JOURNAL OF CELL BIOLOGY, 1998, 142 (05) :1325-1335

[4] Rho GTPases and the actin cytoskeleton [J].

Hall, A .

SCIENCE, 1998, 279 (5350) :509-514

[5] Direct interaction of the Wiskott-Aldrich syndrome protein with the GTPase Cdc42 [J].

Kolluri, R ;

Tolias, KF ;

Carpenter, CL ;

Rosen, FS ;

Kirchhausen, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (11) :5615-5618

[6] Use of a fluorescence spectroscopic readout to characterize the interactions of Cdc42Hs with its target/effector, mPAK-3 [J].

Leonard, DA ;

Satoskar, RS ;

Wu, WJ ;

Bagrodia, S ;

Cerione, RA ;

Manor, D .

BIOCHEMISTRY, 1997, 36 (05) :1173-1180

[7] Bee1, a yeast protein with homology to Wiscott-Aldrich syndrome protein, is critical for the assembly of cortical actin cytoskeleton [J].

Li, R .

JOURNAL OF CELL BIOLOGY, 1997, 136 (03) :649-658

[8] The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42 [J].

Ma, L ;

Rohatgi, R ;

Kirschner, MW .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15362-15367

[9] Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex [J].

Machesky, LM ;

Mullins, RD ;

Higgs, HN ;

Kaiser, DA ;

Blanchoin, L ;

May, RC ;

Hall, ME ;

Pollard, TD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (07) :3739-3744

[10] Cell motility: Complex dynamics at the leading edge [J].

Machesky, LM .

CURRENT BIOLOGY, 1997, 7 (03) :R164-R167

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