The effect of chronic nasal application of chitosan solutions on cilia beat frequency in guinea pigs

被引：44

作者：

Aspden, T

Illum, L

Skaugrud, O

机构：

[1] UNIV NOTTINGHAM,DEPT PHARMACEUT SCI,NOTTINGHAM NG7 2RD,ENGLAND

[2] DANBIOSYST UK LTD,ALBERT EINSTEIN CTR,NOTTINGHAM NG7 2TN,ENGLAND

[3] PRONOVA BIOMED,N-0371 OSLO,NORWAY

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1997年 / 153卷 / 02期

关键词：

cilia beat frequency; guinea pigs; chitosan; nasal administration; nasal toxicity;

D O I：

10.1016/S0378-5173(97)04914-4

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The cilia beat frequency (CBF) was evaluated in guinea pigs after daily nasal administration of various chitosan solutions for 28 days. The chitosans tested were of various molecular weights and degree of deacetylation. The effect of the chitosans on the CBF was measured on the excised nasal tissue and compared to the effect of sodium taurodihydrofusidate and cocaine by means of a microscope connected to a video camera mounted on the phototube and a data acquisition unit. The results showed that none of the chitosans tested has any effect on the CBF as compared to the controls. (C) 1997 Elsevier Science B.V.

引用

收藏

页码：137 / 146

页数：10

相关论文

共 37 条

[1]

EFFECT OF CHITOSAN ON THE PERMEABILITY OF MONOLAYERS OF INTESTINAL EPITHELIAL-CELLS (CACO-2) [J].

ARTURSSON, P ;

LINDMARK, T ;

DAVIS, SS ;

ILLUM, L .

PHARMACEUTICAL RESEARCH, 1994, 11 (09) :1358-1361

[2]

Chitosan as a nasal delivery system: The effect of chitosan solutions on in vitro and in vivo mucociliary transport rates in human turbinates and volunteers [J].

Aspden, TJ ;

Mason, JDT ;

Jones, NS ;

Lowe, J ;

Skaugrud, O ;

Illum, L .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1997, 86 (04) :509-513

[3]

THE EFFECT OF SOME PRESERVATIVES USED IN NASAL PREPARATIONS ON THE MUCUS AND CILIARY COMPONENTS OF MUCOCILIARY CLEARANCE [J].

BATTS, AH ;

MARRIOTT, C ;

MARTIN, GP ;

WOOD, CF ;

BOND, SW .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1990, 42 (03) :145-151

[4]

THE LACK OF EFFECT OF BENZALKONIUM CHLORIDE ON THE CILIA OF THE NASAL-MUCOSA IN PATIENTS WITH PERENNIAL ALLERGIC RHINITIS - A COMBINED FUNCTIONAL, LIGHT, SCANNING AND TRANSMISSION ELECTRON-MICROSCOPY STUDY [J].

BRAAT, JPM ;

AINGE, G ;

BOWLES, JAK ;

RICHARDS, DH ;

VANRIESSEN, D ;

VISSER, WJ ;

RIJNTJES, E .

CLINICAL AND EXPERIMENTAL ALLERGY, 1995, 25 (10) :957-965

[5]

ABSORPTION OF RECOMBINANT METHIONYL-HUMAN GROWTH-HORMONE (MET-HGH) FROM RAT NASAL-MUCOSA [J].

DAUGHERTY, AL ;

LIGGITT, HD ;

MCCABE, JG ;

MOORE, JA ;

PATTON, JS .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1988, 45 (03) :197-206

[6]

BILE-SALTS AND INTRANASAL DRUG ABSORPTION [J].

DUCHATEAU, GSMJE ;

ZUIDEMA, J ;

MERKUS, FWHM .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1986, 31 (03) :193-199

[7]

THE EFFECTS OF PERMEATION ENHANCERS ON THE SURFACE-MORPHOLOGY OF THE RAT NASAL-MUCOSA - A SCANNING ELECTRON-MICROSCOPY STUDY [J].

ENNIS, RD ;

BORDEN, L ;

LEE, WA .

PHARMACEUTICAL RESEARCH, 1990, 7 (05) :468-475

[8]

SPECTRAL CHARACTERIZATION OF CILIARY BEATING - VARIATIONS OF FREQUENCY WITH TIME [J].

ESHEL, D ;

GROSSMAN, Y ;

PRIEL, Z .

AMERICAN JOURNAL OF PHYSIOLOGY, 1985, 249 (01) :C160-C165

[9]

Fabricant ND, 1941, ARCHIV OTOLARYNGOL, V34, P150

[10]

MUCOCILIARY FLOW IN TRACHEA DURING ANESTHESIA WITH ENFLURANE, ETHER, NITROUS-OXIDE, AND MORPHINE [J].

FORBES, AR ;

HORRIGAN, RW .

ANESTHESIOLOGY, 1977, 46 (05) :319-321

← 1 2 3 4 →