Human CD4(+) T-cell recognition of influenza A virus hemagglutinin after subunit vaccination

被引：26

作者：

Gelder, CM ^{[1
]}

Lamb, JR ^{[1
]}

Askonas, BA ^{[1
]}

机构：

[1] UNIV LONDON IMPERIAL COLL SCI TECHNOL & MED, DEPT BIOL, INFECT & IMMUN SECT, LONDON SW7 2BB, ENGLAND

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1128/JVI.70.7.4787-4790.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have examined human CD4(+) T-cell recognition of influenza A/Beijing/32/92 (H3N2) virus hemagglutinin following influenza virus HANA subunit vaccination. CD4(+)-cell repertoires were dominated by recognition df epitopes located in conserved regions of the molecule, in a major histocompatibility complex class II haplotype-dependent manner, analogous to that observed following natural infection.

引用

页码：4787 / 4790

页数：4

共 14 条

[1] ANDERS EM, 1979, J IMMUNOL, V123, P1356
[2] ASKONAS BA, 1988, IMMUNOLOGY, P51
[3] BIDDISON WE, 1981, J IMMUNOL, V127, P487
[4] ANTIGENIC DRIFT IN INFLUENZA VIRUS-H3 HEMAGGLUTININ FROM 1968 TO 1980 - MULTIPLE EVOLUTIONARY PATHWAYS AND SEQUENTIAL AMINO-ACID CHANGES AT KEY ANTIGENIC SITES
BOTH, GW
SLEIGH, MJ
COX, NJ
KENDAL, AP
[J]. JOURNAL OF VIROLOGY, 1983, 48 (01) : 52 - 60
[5] THE ROLE OF IL-2 AND T4+ CELLS IN THE GENERATION OF HUMAN INFLUENZA VIRUS-SPECIFIC CTL ACTIVITY
BRAAKMAN, E
TREEPVANLEEUWEN, P
ROOSNEK, EE
LUCAS, CJ
[J]. CELLULAR IMMUNOLOGY, 1986, 100 (02) : 462 - 473
[6] THYMUS DEPENDENCE OF VIRAL ANTIGENS
BURNS, WH
BILLUPS, LC
NOTKINS, AL
[J]. NATURE, 1975, 256 (5519) : 654 - 666
[7] COX N, COMMUNICATION
[8] HUMAN CD4(+) T-CELL REPERTOIRE OF RESPONSES TO INFLUENZA-A VIRUS HEMAGGLUTININ AFTER RECENT NATURAL INFECTION
GELDER, CM
WELSH, KI
FAITH, A
LAMB, JR
ASKONAS, BA
[J]. JOURNAL OF VIROLOGY, 1995, 69 (12) : 7497 - 7506
[9] LIGHTMAN S, 1987, IMMUNOLOGY, V62, P139
[10] McMichael A, 1994, Curr Top Microbiol Immunol, V189, P75

← 1 2 →