Acid tolerance of gastrointestinal pathogens

被引：151

作者：

Merrell, DS

Camilli, A

机构：

[1] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[2] Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA

来源：

CURRENT OPINION IN MICROBIOLOGY | 2002年 / 5卷 / 01期

关键词：

D O I：

10.1016/S1369-5274(02)00285-0

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The ability of pathogenic bacteria to survive in the face of host defense systems is intimately linked to virulence. This is exemplified by gastrointestinal pathogens that must survive exposure to extreme acid conditions within the stomach and organic acid conditions within the small intestine. These organisms have evolved complex systems to respond to acid stress, and recent work has revealed new genetic components involved in survival and virulence. Here, we review recent work on four gastrointestinal pathogens, focusing on studies that reveal both acid-inducible resistance systems and inherent (basal state) acid-resistance systems.

引用

收藏

页码：51 / 55

页数：5

相关论文

共 37 条

[1] CHARACTERIZATION OF THE CARBON STARVATION-INDUCIBLE AND STATIONARY PHASE-INDUCIBLE GENE SIP ENCODING AN OUTER-MEMBRANE LIPOPROTEIN IN ESCHERICHIA-COLI [J].

ALEXANDER, DM ;

STJOHN, AC .

MOLECULAR MICROBIOLOGY, 1994, 11 (06) :1059-1071

[2] Global analysis of Escherichia coli gene expression during the acetate-induced acid tolerance response [J].

Arnold, CN ;

McElhanon, J ;

Lee, A ;

Leonhart, R ;

Siegele, DA .

JOURNAL OF BACTERIOLOGY, 2001, 183 (07) :2178-2186

[3] ACID TOLERANCE OF ENTEROHEMORRHAGIC ESCHERICHIA-COLI [J].

BENJAMIN, MM ;

DATTA, AR .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1995, 61 (04) :1669-1672

[4] Control of acid resistance in Escherichia coli [J].

Castanie-Cornet, MP ;

Penfound, TA ;

Smith, D ;

Elliott, JF ;

Foster, JW .

JOURNAL OF BACTERIOLOGY, 1999, 181 (11) :3525-3535

[5] Escherichia coli acid resistance:: cAMP receptor protein and a 20 bp cis-acting sequence control pH and stationary phase expression of the gadA and gadBC glutamate decarboxylase genes [J].

Castanie-Cornet, MP ;

Foster, JW .

MICROBIOLOGY-UK, 2001, 147 :709-715

[6] Membrane cyclopropane fatty acid content is a major factor in acid resistance of Escherichia coli [J].

Chang, YY ;

Cronan, JE .

MOLECULAR MICROBIOLOGY, 1999, 33 (02) :249-259

[7] rpoS regulation of acid, heat, and salt tolerance in Escherichia coli O157:H7 [J].

Cheville, AM ;

Arnold, KW ;

Buchrieser, C ;

Cheng, CM ;

Kaspar, CW .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1996, 62 (05) :1822-1824

[8] Contribution of dps to acid stress tolerance and oxidative stress tolerance in Escherichia coli O157:H7 [J].

Choi, SH ;

Baumler, DJ ;

Kaspar, CW .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2000, 66 (09) :3911-3916

[9] Bacterial virulence gene regulation: An evolutionary perspective [J].

Cotter, PA ;

DiRita, VJ .

ANNUAL REVIEW OF MICROBIOLOGY, 2000, 54 :519-565

[10] A glutamate decarboxylase system protects Listeria monocytogenes in gastric fluid [J].

Cotter, PD ;

Gahan, CGM ;

Hill, C .

MOLECULAR MICROBIOLOGY, 2001, 40 (02) :465-475

← 1 2 3 4 →