The role of lipopolysaccharide-binding protein in modulating the innate immune response

被引：143

作者：

Zweigner, Janine

Schumann, Ralf R.

Weber, Joerg R.

机构：

[1] Charite Univ Med Berlin, Dept Neurol, D-10117 Berlin, Germany

[2] Charite Univ Med Berlin, Inst Microbiol & Hyg, D-10117 Berlin, Germany

来源：

MICROBES AND INFECTION | 2006年 / 8卷 / 03期

关键词：

lipopolysaccharide; lipopolysaccharide-binding protein; immune response; gram-positive pathogens; SEPSIS;

D O I：

10.1016/j.micinf.2005.10.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lipopolysaccharide-binding protein (LBP) has a well-established role in Gram-negative infection. New data suggest a more expanded role for LBP as a general recognition molecule. Several bacterial surface components from Gram-positive pathogens are also recognized by this molecule. LBP may also serve as a clinical marker in severe infections and may carry therapeutic potential. (c) 2005 Elsevier SAS. All rights reserved.

引用

收藏

页码：946 / 952

页数：7

相关论文

共 63 条

[1] Lipopolysaccharide-binding protein increases toll-like receptor 4-dependent activation by nontypeable Haemophilus influenzae [J].

Ahrén, IL ;

Bjartell, A ;

Egesten, A ;

Riesbeck, K .

JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (07) :926-930

[2]

Beamer LJ, 1998, PROTEIN SCI, V7, P906

[3] The three-dimensional structure of human bactericidal permeability-increasing protein - Implications for understanding protein-lipopolysaccharide interactions [J].

Beamer, LJ ;

Carroll, SF ;

Eisenberg, D .

BIOCHEMICAL PHARMACOLOGY, 1999, 57 (03) :225-229

[4] Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution [J].

Beamer, LJ ;

Carroll, SF ;

Eisenberg, D .

SCIENCE, 1997, 276 (5320) :1861-1864

[5] THE STRUCTURE OF PNEUMOCOCCAL LIPOTEICHOIC ACID - IMPROVED PREPARATION, CHEMICAL AND MASS-SPECTROMETRIC STUDIES [J].

BEHR, T ;

FISCHER, W ;

PETERKATALINIC, J ;

EGGE, H .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1992, 207 (03) :1063-1075

[6] Lipopolysaccharide binding protein in preterm infants [J].

Behrendt, D ;

Dembinski, J ;

Heep, A ;

Bartmann, P .

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2004, 89 (06) :F551-F554

[7] PLUNC: A novel family of candidate host defence proteins expressed in the upper airways and nasopharynx [J].

Bingle, CD ;

Craven, CJ .

HUMAN MOLECULAR GENETICS, 2002, 11 (08) :937-943

[8] Lipopolysaccharide-binding protein serum levels in patients with severe sepsis due to gram-positive and fungal infections [J].

Blairon, L ;

Wittebole, X ;

Laterre, PF .

JOURNAL OF INFECTIOUS DISEASES, 2003, 187 (02) :287-291

[9] Production of the acute-phase protein lipopolysaccharide-binding protein by respiratory type II epithelial cells - Implications for local defense to bacterial endotoxins [J].

Dentener, MA ;

Vreugdenhil, ACE ;

Hoet, PHM ;

Vernooy, JHJ ;

Nieman, FHM ;

Heumann, D ;

Janssen, YMW ;

Buurman, WA ;

Wouters, EFM .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2000, 23 (02) :146-153

[10] A hydrophobic cluster at the surface of the human plasma phospholipid transfer protein is critical for activity on high density lipoproteins [J].

Desrumaux, C ;

Labeur, C ;

Verhee, A ;

Tavernier, J ;

Vandekerckhove, J ;

Rosseneu, M ;

Peelman, F .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (08) :5908-5915

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