Antarctic isolation: Immune and viral studies

被引:48
作者
Tingate, TR
Lugg, DJ
Muller, HK
Stowe, RP
Pierson, DL
机构
[1] POLAR MED,AUSTRALIAN ANTARCTIC DIV,KINGSTON,TAS,AUSTRALIA
[2] KRUG LIFE SCI INC,HOUSTON,TX
[3] NASA,LYNDON B JOHNSON SPACE CTR,LIFE SCI RES LABS,HOUSTON,TX 77058
关键词
Antarctica; cell-mediated immunity; CMI Multitest; cytokines; herpesvirus; isolation; monocytes; phytohaemagglutinin; stress; HUMAN MONONUCLEAR LEUKOCYTES; CELL-MEDIATED-IMMUNITY; DURATION MISSIONS; STRESS; CONFINEMENT; IMMUNOCOMPETENCE; LYMPHOCYTE; ENDOCRINE; RESPONSES;
D O I
10.1038/icb.1997.42
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Stressful environmental conditions ape a major determinant of immune reactivity. This effect is pronounced in Australian National Antarctic Research Expedition populations exposed to prolonged periods of isolation in the Antarctic. Alterations of T cell function, including depression of cutaneous delayed-type hypersensitivity responses and a peak 48.9% reduction of T cell proliferation to the mitogen phytohaemagglutinin, were documented during a 9-month period of isolation. T cell dysfunction was mediated by changes within the peripheral blood mononuclear cell compartment, including a paradoxical atypical monocytosis associated with altered production of inflammatory cytokines. There was a striking reduction in the production by peripheral blood mononuclear cells of the predominant pro-inflammatory monokine TNF-alpha and changes were also detected in the production of IL-1, IL-2, IL-6, IL-1ra and IL-10. Prolonged Antarctic isolation is also associated with altered latent herpesvirus homeostasis, including increased herpesvirus shedding and expansion of the polyclonal latent Epstein-Barr virus-infected B cell population. These findings have important long-term health implications.
引用
收藏
页码:275 / 283
页数:9
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