Colorectal Cancer Migration and Invasion Initiated by microRNA-106a

被引：80

作者：

Feng, Bo ^{[1
,2
,3
]}

Dong, Tao Tao ^{[4
]}

Wang, Lin Lin ^{[5
]}

Zhou, Hou Min ^{[1
,2
,3
]}

Zhao, Hong Chao ^{[1
,2
,3
]}

Dong, Feng ^{[1
]}

Zheng, Min Hua ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, Dept Surg, Shanghai 200030, Peoples R China

[2] Shanghai Inst Digest Surg, Shanghai, Peoples R China

[3] Shanghai Minimally Invas Surg Ctr, Shanghai, Peoples R China

[4] Shandong Univ, Qilu Hosp, Dept Obstet & Gynecol, Jinan 250100, Shandong, Peoples R China

[5] Shanghai Jiao Tong Univ, Sch Med, Shanghai Childrens Hosp, Shanghai Inst Med Genet, Shanghai 200030, Peoples R China

来源：

PLOS ONE | 2012年 / 7卷 / 08期

关键词：

TGF-BETA; TUMOR-METASTASIS; CELL-GROWTH; EXPRESSION; RECEPTOR; GENE; CARCINOMA; TARGET; ADENOCARCINOMA; INHIBITION;

D O I：

10.1371/journal.pone.0043452

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

MicroRNAs have been implicated in the regulation of several cellular signaling pathways of colorectal cancer (CRC) cells. Although emerging evidence proves that microRNA (miR)-106a is expressed highly in primary tumor and stool samples of CRC patients; whether or not miR-106a mediates cancer metastasis is unknown. We show here that miR-106a is highly expressed in metastatic CRC cells, and regulates cancer cell migration and invasion positively in vitro and in vivo. These phenotypes do not involve confounding influences on cancer cell proliferation. MiR-106a inhibits the expression of transforming growth factor-beta receptor 2 (TGFBR2), leading to increased CRC cell migration and invasion. Importantly, miR-106a expression levels in primary CRCs are correlated with clinical cancer progression. These observations indicate that miR-106a inhibits the anti-metastatic target directly and results in CRC cell migration and invasion.

引用

页数：9

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