Association of a CB1 cannabinoid receptor gene (CNR1) polymorphism with severe alcohol dependence

被引：119

作者：

Schmidt, LG

Samochowiec, J

Finckh, U

Fiszer-Piosik, E

Horodnicki, J

Wendel, B

Rommelspacher, H

Hoehe, MR

机构：

[1] Univ Mainz, Dept Psychiat, D-55131 Mainz, Germany

[2] Pomeranian Acad Med, Dept Psychiat, PL-71460 Szczecin, Poland

[3] Free Univ Berlin, Univ Hosp Benjamin Franklin, Dept Clin Neurobiol, D-14050 Berlin, Germany

[4] Univ Hosp Eppendorf, Dept Human Genet, D-22529 Hamburg, Germany

[5] Max Delbruck Ctr Mol Med, D-13092 Berlin, Germany

来源：

DRUG AND ALCOHOL DEPENDENCE | 2002年 / 65卷 / 03期

关键词：

CB1 cannabinoid receptor gene (CNR1); alcoholism; alcohol withdrawal; alcohol seizures; genetics;

D O I：

10.1016/S0376-8716(01)00164-8

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Due to the involvement of the endogenous cannabinoid system in brain reward mechanisms a silent polymorphism (1359G/A; Thr453Thr) in the single coding exon of the CB1 human cannabinoid receptor gene (CNR1) was analysed in 121 severely affected Caucasian alcoholics and 136 roost likely non-alcoholic controls. The observed frequency of the A allele was 31.2% for controls and 42.1% for alcoholics with severe withdrawal syndromes (P = 0.010). Post-hoc exploration indicated that this allelic association resulted from an excess of the homozygous A/A genotype in patients with a history of alcohol delirium (P = 0.031, DF 2), suggesting an increased risk of delirium (OR = 2.45, 95% CI 1.14-5.25). This finding suggests that the homozygous genotype CNR1 1359A/A confers vulnerability to alcohol withdrawal delirium. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：221 / 224

页数：4

共 23 条

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