Endothelial activation and dysfunction in the pathogenesis of influenza A virus infection

被引：88

作者：

Armstrong, Susan M. ^{[1
]}

Darwish, Ilyse ^{[2
]}

Lee, Warren L. ^{[3
,4
,5
]}

机构：

[1] Univ Toronto, Fac Med, Inst Med Sci, Toronto, ON, Canada

[2] Toronto Gen Hosp, Univ Hlth Network, Sandra Rotman Ctr Global Hlth, Sandra A Rotman Labs, Toronto, ON, Canada

[3] Univ Toronto, Fac Med, Div Respirol, Toronto, ON, Canada

[4] Univ Toronto, Fac Med, Interdept Div Crit Care Med, Toronto, ON, Canada

[5] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr, Toronto, ON M5B 1W8, Canada

来源：

VIRULENCE | 2013年 / 4卷 / 06期

基金：

加拿大健康研究院;

关键词：

endothelium; microvascular leak; influenza A; platelets; thrombosis; acute lung injury; TUMOR-NECROSIS-FACTOR; NEUTROPHIL EXTRACELLULAR TRAPS; ACUTE LUNG INJURY; CRITICALLY-ILL PATIENTS; FACTOR-ALPHA; REDUCED RISK; CELLS; TNF; INTERLEUKIN-1; INFLAMMATION;

D O I：

10.4161/viru.25779

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The development of severe influenza has been attributed, in part, to a heightened innate immune response. Recent evidence suggests that endothelial activation, loss of barrier function, and consequent microvascular leak may also serve important mechanistic roles in the pathogenesis of severe influenza. The aim of this review is to summarize the current evidence in support of endothelial activation and dysfunction as a central feature preceding the development of severe influenza. We also discuss the effect of influenza on platelet-endothelial interactions.

引用

页码：537 / 542

页数：6

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