Cytokine regulation in RA synovial tissue: role of T cell/macrophage contact-dependent interactions

被引：33

作者：

Brennan, Fionula Mary ^{[1
]}

Foey, Andrew David ^{[1
]}

机构：

[1] Imperial Coll Sci Technol & Med, Fac Med, Kennedy Inst, Div Rheumatol, 1 Aspenlea Rd, London W6 8LH, England

来源：

ARTHRITIS RESEARCH & THERAPY | 2002年 / 4卷 / Suppl 3期

基金：

英国惠康基金;

关键词：

cognate; differentiation; macrophage; signalling; T cells;

D O I：

10.1186/ar556

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several groups have documented the expression of cytokines in rheumatoid arthritis synovial tissue over the past 15 years or so. These studies have indicated that most cytokines examined are expressed at the mRNA levels at least, and many other cytokines are found in abundance as proteins. Our attention has recently focused on the mechanisms that induce and regulate tumour necrosis factor and IL-10. Other workers and ourselves have found that cell-cell contact is an important signal for the induction of cytokines, and our work has demonstrated that tumour necrosis factor and IL-10 production in rheumatoid arthritis synovial joint cells cultures is dependent on T cell/macrophage interaction. In this chapter, we review recent advances in this area and also highlight areas where new therapeutic intervention opportunities arise.

引用

页码：S177 / S182

页数：6

共 55 条

[1] Defining therapeutic targets by using adenovirus:: Blocking NF-κB inhibits both inflammatory and destructive mechanisms in rheumatoid synovium but spares anti-inflammatory mediators [J].