Postnatal development of action potential-induced dendritic calcium entry in neocortical layer II/III pyramidal cells

被引：9

作者：

Isomura, Y

Yamamoto, K

Hashimoto, K

Kato, N ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Integrat Brain Sci, Kyoto 6068501, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Neurol, Kyoto 6068501, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Neurosurg, Kyoto 6068501, Japan

[4] Japan Sci & Technol Corp, Saitama 3320012, Japan

来源：

BRAIN RESEARCH | 1999年 / 832卷 / 1-2期

基金：

日本科学技术振兴机构;

关键词：

fura-2; rat; spike; visual cortex; voltage-dependent calcium channel;

D O I：

10.1016/S0006-8993(99)01431-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

By whole-cell patch-clamp recording and calcium imaging with fura-2, we investigated postnatal development of intracellular calcium dynamics in apical dendrites of layer II/III pyramidal cells in the rat visual cortex. Dendritic calcium increases, induced by single action potentials, occurred only slightly on postnatal days 8-10 (P8-10), and then underwent a gradual enhancement during the second postnatal week to become 2-3-fold larger on P16-18 than on P8-10. The results suggest that the developmental growth of calcium dynamics may play a critical role for functional development of neocortical neurons. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：175 / 178

页数：4

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