Mechanisms of resistance of Plasmodium falciparum to antimalarial drugs

被引：120

作者：

Hyde, JE ^{[1
]}

机构：

[1] UMIST, Dept Biomol Sci, Manchester M60 1QD, Lancs, England

来源：

MICROBES AND INFECTION | 2002年 / 4卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

antifolates; chloroquine; mefloquine; quinine; halofantrine; artemisinin; atovaquone;

D O I：

10.1016/S1286-4579(01)01524-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Chemotherapy and chemoprophylaxis are the principal means of combating malaria parasite infections in the human host. In the last 75 years, since the introduction of synthetic antimalarials, only a small number of compounds have been found suitable for clinical usage, and this limited armoury is now greatly compromised by the spread of drug-resistant parasite strains. Our current knowledge of the molecular mechanisms underlying resistance in the lethal species Plasmodium falciparum is reviewed here. (C) 2002 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：165 / 174

页数：10

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